Polymer excipients enable sustained drug release in low pH from mechanically strong inorganic geopolymers
| Autor: | Håkan Engqvist, Bing Cai, Susanne Bredenberg, Maria Strømme, Tejaswi Yarra, Erik Jämstorp |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Materials science
Sociology and Political Science Polymers Pellets Excipient Pharmaceutical Science Article Dosage form Education PEG ratio medicine Controlled release chemistry.chemical_classification Geopolymers Polymer LPN and LVN Opioids Oral administration Geopolymer Compressive strength chemistry Chemical engineering Law Acidic conditions medicine.drug Biomedical engineering |
| Zdroj: | Results in Pharma Sciences. 2:23-28 |
| ISSN: | 2211-2863 |
| DOI: | 10.1016/j.rinphs.2012.02.001 |
| Popis: | Improving acid resistance, while maintaining the excellent mechanical stability is crucial in the development of a sustained and safe oral geopolymer dosage form for highly potent opioids. In the present work, commercially available Methacrylic acid–ethyl acrylate copolymer, Polyethylene-glycol (PEG) and Alginate polymer excipients were included in dissolved or powder form in geopolymer pellets to improve the release properties of Zolpidem, herein acting as a model drug for the highly potent opioid Fentanyl. Scanning electron microscopy, compression strength tests and drug release experiments, in gastric pH 1 and intestinal pH 6.8 conditions, were performed. The polymer excipients, with an exception for PEG, reduced the drug release rate in pH 1 due to their ability to keep the pellets in shape, in combination with the introduction of an insoluble excipient, and thereby maintain a barrier towards drug diffusion and release. Neither geopolymer compression strength nor the release in pH 6.8 was considerably impaired by the incorporation of the polymer excipients. The geopolymer/polymer composites combine high mechanical strength and good release properties under both gastric and intestinal pH conditions, and are therefore promising oral dosage forms for sustained release of highly potent opioids. |
| Databáze: | OpenAIRE |
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