Increased echocardiographic epicardial fat thickness is related to impaired diurnal blood pressure profiles

Autor:	Ebru Tekbas, Yahya Islamoglu, Mesut Aydin, Abdurrahman Akyüz, Mehmet Serdar Soydinç, Faruk Ertaş, Zuhal Arıtürk, H. Cil, Hasan Kaya, Halit Acet
Rok vydání:	2012
Předmět:	Male medicine.medical_specialty Ambulatory blood pressure Blood Pressure Fats Risk Factors Internal medicine Area under curve Internal Medicine medicine Humans Echocardiography transthoracic Obesity Hypertensive group Cardiometabolic risk biology business.industry Dipper General Medicine Middle Aged biology.organism_classification Echocardiography Doppler Epicardial fat Circadian Rhythm Endocrinology Blood pressure Adipose Tissue Echocardiography Clinical diagnosis Ambulatory Epicardial adipose tissue Cardiology Cardiology and Cardiovascular Medicine business Pericardium
Zdroj:	ResearcherID
ISSN:	1651-1999 0803-7051
DOI:	10.3109/08037051.2011.649538
Popis:	Epicardial fat has been proposed as a new cardiometabolic risk factor. Although epicardial fat thickness (EFT) is associated with hypertension, the relationship between diurnal blood pressure profiles and EFT is still unknown. The purpose of this study is to investigate the association between the echocardiographic EFT and diurnal blood pressure profiles in hypertensive patients.After the ambulatory blood pressures of 123 patients were monitored, they were divided into three groups according to the clinical diagnoses: 41 patients (33.3%) were in the normotensive group, 40 patients (32.5%) were in the dipper hypertensive group and 42 patients (34.1%) were in the non-dipper hypertensive group. All participants underwent transthoracic echocardiography and ambulatory blood pressure monitoring to measure the EFT and blood pressure responses.The mean EFT measurements of the dipper group were significantly higher than the normotensive group (6.5 ± 0.6 vs 5.8 ± 0.6; p0.0001). On the other hand, the mean EFTs of the non-dipper group were also significantly higher than the dipper group (7.4 ± 0.7 vs 6.5 ± 0.6, p0.0001). An EFT of ≥ 7 mm predicted the non-dipper profile in hypertensive patients with 74% sensitivity and 71% specificity (receiving operator characteristic area under the curve: 0.826, 95% CI 0.738-0.913; p0.0001). EFT was associated with both dipper (OR 8.9, 95% CI 3.03-26.3; p0.0001) and non-dipper blood pressure profiles (OR 12.3, 95% CI 1.75-86.31; p0.0001), and this relationship was also independent from all the risk factors.Echocardiographic EFT assessment is independently associated with impaired diurnal blood pressure profiles in the hypertensive individuals. Thus, the echocardiographic assessment of the EFT may be helpful in cardiometabolic risk stratification and therapeutic interventions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::484f56dd4f71b3b69a66af2907358c80 https://doi.org/10.3109/08037051.2011.649538 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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