DREMECELS: A Curated Database for Base Excision and Mismatch Repair Mechanisms Associated Human Malignancies
| Autor: | Ahmed Moussa, Tiratha Raj Singh, Ankita Shukla |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine lcsh:Medicine Disease Bioinformatics computer.software_genre DNA Mismatch Repair Biochemistry Database and Informatics Methods 0302 clinical medicine Medicine and Health Sciences Drug Interactions Copy-number variation lcsh:Science DNA methylation Multidisciplinary Database Base excision repair Chromatin Lynch syndrome Nucleic acids Oncology 030220 oncology & carcinogenesis Female Epigenetics DNA mismatch repair Databases Nucleic Acid DNA modification Chromatin modification Research Article Chromosome biology Cell biology DNA repair Biology Research and Analysis Methods 03 medical and health sciences Germline mutation DNA-binding proteins Genetics medicine Humans Non-coding RNA Pharmacology Colorectal Cancer Biology and life sciences lcsh:R Proteins Cancers and Neoplasms Cancer DNA medicine.disease Colorectal Neoplasms Hereditary Nonpolyposis Gene regulation Regulatory Proteins MicroRNAs Biological Databases 030104 developmental biology Mutation Mutation Databases Somatic Mutation RNA lcsh:Q Gene expression computer Transcription Factors |
| Zdroj: | PLoS ONE PLoS ONE, Vol 11, Iss 6, p e0157031 (2016) |
| ISSN: | 1932-6203 |
| Popis: | DNA repair mechanisms act as a warrior combating various damaging processes that ensue critical malignancies. DREMECELS was designed considering the malignancies with frequent alterations in DNA repair pathways, that is, colorectal and endometrial cancers, associated with Lynch syndrome (also known as HNPCC). Since lynch syndrome carries high risk (~40-60%) for both cancers, therefore we decided to cover all three diseases in this portal. Although a large population is presently affected by these malignancies, many resources are available for various cancer types but no database archives information on the genes specifically for only these cancers and disorders. The database contains 156 genes and two repair mechanisms, base excision repair (BER) and mismatch repair (MMR). Other parameters include some of the regulatory processes that have roles in these disease progressions due to incompetent repair mechanisms, specifically BER and MMR. However, our unique database mainly provides qualitative and quantitative information on these cancer types along with methylation, drug sensitivity, miRNAs, copy number variation (CNV) and somatic mutations data. This database would serve the scientific community by providing integrated information on these disease types, thus sustaining diagnostic and therapeutic processes. This repository would serve as an excellent accompaniment for researchers and biomedical professionals and facilitate in understanding such critical diseases. DREMECELS is publicly available at http://www.bioinfoindia.org/dremecels. |
| Databáze: | OpenAIRE |
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