An Unnatural Biopolymer
| Autor: | Jeffrey W. Jacobs, Stephen P. A. Fodor, Edmund J. Moran, Charles Y. Cho, Cynthia L. Adams, Peter G. Schultz, Arathi Sundaram, James C. Stephans, Sara Cherry |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Octanol
Molecular Sequence Data Carbonates Peptide engineering.material Oligomer Epitopes Mice chemistry.chemical_compound Biopolymers Side chain Animals Organic chemistry Amino Acid Sequence chemistry.chemical_classification Mice Inbred BALB C Multidisciplinary Antibodies Monoclonal Polymer Combinatorial chemistry Folding (chemistry) Monomer chemistry engineering Biopolymer Oligopeptides |
| Zdroj: | Science. 261:1303-1305 |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.7689747 |
| Popis: | A highly efficient method has been developed for the solid-phase synthesis of an "unnatural biopolymer" consisting of chiral aminocarbonate monomers linked via a carbamate backbone. Oligocarbamates were synthesized from N-protected p-nitrophenyl carbonate monomers, substituted with a variety of side chains, with greater than 99 percent overall coupling efficiencies per step. A spatially defined library of oligocarbamates was generated by using photochemical methods and screened for binding affinity to a monoclonal antibody. A number of high-affinity ligands were then synthesized and analyzed in solution with respect to their inhibition concentration values, water/octanol partitioning coefficients, and proteolytic stability. These and other unnatural polymers may provide new frameworks for drug development and for testing theories of protein and peptide folding and structure. |
| Databáze: | OpenAIRE |
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