Graft biomechanical properties after penetrating keratoplasty in keratoconus
| Autor: | Sepehr Feizi, Bahram Einollahi, Ali Hashemloo, Shahin Yazdani |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Keratoconus Intraocular pressure genetic structures Adolescent Corneal graft Normal values Corneal hysteresis Cornea Young Adult Patient age Ophthalmology medicine Humans Intraocular Pressure business.industry Goldmann Applanation Tonometer medicine.disease eye diseases Elasticity Tissue Donors Biomechanical Phenomena Cross-Sectional Studies Trephine Female sense organs business Keratoplasty Penetrating |
| Zdroj: | Cornea. 31(8) |
| ISSN: | 1536-4798 |
| Popis: | PURPOSE To measure corneal graft biomechanical properties after penetrating keratoplasty (PKP) in a group of keratoconic eyes using the ocular response analyzer (ORA) and to evaluate the relationship between donor size, donor-recipient disparity and central graft thickness (CGT), and ORA parameters. METHODS This cross-sectional study was conducted on 34 eyes of 34 keratoconus patients who had undergone PKP. Corneal hysteresis (CH), corneal resistance factor (CRF), and cornea-compensated intraocular pressure were measured at least 6 months after complete suture removal. Two groups of donor-recipient disparity (0.25 vs. 0.50 mm) were compared using the independent t test. Multivariate regression analysis was used to investigate the correlation of donor trephine size and CGT with ORA parameters. Factors influencing intraocular pressure measured with the Goldmann applanation tonometer (IOP GAT) after PKP were determined using multiple regression analysis. RESULTS Mean patient age and follow-up period were 29.6 ± 6.2 years and 82.4 ± 59.6 months, respectively. Mean CGT, CH, and CRF were 564.7 ± 36.9 μm, 10.1 ± 2.1 mm Hg, and 10.0 ± 2.3 mm Hg, respectively. CH and CRF had a significant positive correlation with donor trephine size and CGT. Significantly greater values of CH and CRF were observed in the 0.5-mm disparity group compared with the 0.25-mm disparity group. Among the studied parameters, only CH, CRF, and cornea-compensated intraocular pressure had a significant positive correlation with IOP GAT. CONCLUSION Graft biomechanics seem to be closer to normal values with larger grafts and greater donor-recipient disparity. These metrics had a significant correlation with IOP GAT after PKP. |
| Databáze: | OpenAIRE |
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