The Immunological Effect of 8-Methoxypsoralen and UVA Treatment on Murine T-Cell Leukemia
| Autor: | Ting-Ying Cheng, Rong-Hwa Lin, Fung-Win Shen |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
Leukemia T-Cell medicine.medical_treatment Intercellular Adhesion Molecule-1 T-cell leukemia Biology Biochemistry Mice Immune system medicine Animals RNA Messenger RNA Neoplasm Physical and Theoretical Chemistry PUVA Therapy Mice Inbred BALB C Immunogenicity General Medicine medicine.disease In vitro Lymphoma Mice Inbred C57BL PUVA therapy Immunology Cancer research Female sense organs Intracellular |
| Zdroj: | Photochemistry and Photobiology. 64:594-600 |
| ISSN: | 1751-1097 0031-8655 |
| DOI: | 10.1111/j.1751-1097.1996.tb03110.x |
| Popis: | 8-Methoxypsoralen (8-MOP) plus long-wavelength UV radiation (UVA, 320-400 nm) have been used to treat various diseases such as cutaneous T-cell lymphoma, systemic scleroderma, rheumatoid arthritis and rejection of heart transplants. However, the immunological mechanism of this treatment remains unknown. In this report, we investigated the effect of 8-MOP/UVA on the modulation of the immunogenicity of a T-cell leukemia cell line (RL male 1 cells). The results demonstrated that the stimulator function of the in vitro 8-MOP/UVA-treated RL male 1 cells was enhanced in both RL male 1-specific allogeneic and syngeneic immune responses. Furthermore, the enhancement of the immunogenicity of the 8-MOP/UVA-treated RL male 1 cells was found to be strongly associated with the increase of intercellular adhesion molecule-1 expression on these 8-MOP/UVA-treated tumor cells. Therefore, our findings suggested that the alteration of the expression of the immune-related cell surface molecules might be an important effect of 8-MOP/UVA treatment on the elevation of the immunogenicity of the 8-MOP/UVA-treated tumor cells. |
| Databáze: | OpenAIRE |
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