Bone grafts, bone graft extenders, substitutes and enhancers for acetabular reconstruction in revision total hip arthroplasty
| Autor: | Luigi Zagra, Luca Pierannunzii |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Revision Grafts bone Total Hip Arthroplasty Bone morphogenetic protein Bone Graft Substitute 03 medical and health sciences Femoral head 0302 clinical medicine Impaction Grafting medicine Orthopedics and Sports Medicine 030212 general & internal medicine 030222 orthopedics Hip business.industry Impaction Acetabular reconstruction Mesenchymal stem cell Bioceramics Acetabulum Mesenchymal Stem Cells Surgery medicine.anatomical_structure surgical procedures operative Bone Graft Extenders Bone Graft business Bone Graft Enhancers Total hip arthroplasty |
| Zdroj: | EFORT Open Reviews |
| ISSN: | 2058-5241 |
| Popis: | Acetabular bone loss is a relevant concern for surgeons dealing with a failed total hip arthroplasty. Since the femoral head is no longer available, allografts represent the first choice for most reconstructive solutions, either as a structural buttress or impacted bone chips. Even though fresh-frozen bone is firmly recommended for structural grafts, freeze-dried and/or irradiated bone may be used alternatively for impaction grafting. Indeed, there are some papers on freeze-dried or irradiated bone impaction grafting, but their number is limited, as is the number of cases. Xenografts do not represent a viable option based on the poor available evidence but bioactive bioceramics such as hydroxyapatite and biphasic calcium phosphates are suitable bone graft extenders or even substitutes for acetabular impaction grafting. Bone-marrow-derived mesenchymal stem cells and demineralised bone matrix seem to act as reliable bone graft enhancers, i.e. adjuvant therapies able to improve the biological performance of standard bone grafts or substitutes. Among these therapies, platelet-rich plasma and bone morphogenetic proteins need to be investigated further before any recommendations can be made.Cite this article: EFORT Open Rev 2016;1:431-439. DOI:10.1302/2058-5241.160025 |
| Databáze: | OpenAIRE |
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