New 9-Thiocyanatopupukeanane Sesquiterpenes from the Nudibranch Phyllidia varicosa and Its Sponge-Prey Axinyssa aculeata
| Autor: | RuAngelie Edrada-Ebel, Victor Wray, Ru Angelie Edrada, Yasman Yasman, Peter Proksch |
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| Rok vydání: | 2003 |
| Předmět: |
Staphylococcus aureus
Phyllidia varicosa Pharmaceutical Science Brine shrimp Microbial Sensitivity Tests Sesquiterpene Analytical Chemistry chemistry.chemical_compound Candida albicans Drug Discovery Botany Escherichia coli Animals Nuclear Magnetic Resonance Biomolecular Antibacterial agent Pharmacology Molecular Structure biology Organic Chemistry Nudibranch biology.organism_classification Terpenoid Porifera Sponge Complementary and alternative medicine chemistry Indonesia Mollusca Molecular Medicine Artemia Artemia salina Sesquiterpenes Bacillus subtilis |
| Zdroj: | Journal of Natural Products. 66:1512-1514 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np030237j |
| Popis: | Two new 9-thiocyanatopupukeanane sesquiterpene isomers were isolated as major metabolites from the MeOH extract of the sponge Axinyssa aculeata and from its nudibranch predator Phyllidia varicosa. The presence of the sesquiterpenes was monitored by GC-MS, and the structures were confirmed by both 1D and 2D NMR spectroscopy. The isolated sesquiterpenes were found to be toxic toward brine shrimp at LC(50) of 5 ppm. At a dose level of 20 microg, they were found to be weakly and moderately active against B. subtilis and C. albicans, respectively. |
| Databáze: | OpenAIRE |
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