Paired Associative Stimulation of Left and Right Human Motor Cortex Shapes Interhemispheric Motor Inhibition based on a Hebbian Mechanism
| Autor: | Vincenzo Rizzo, Angelo Quartarone, Paolo Girlanda, C. Mastroeni, H.S. Siebner, Francesca Morgante |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Left and right Physiology Cognitive Neuroscience Stimulus (physiology) Functional Laterality Young Adult Cellular and Molecular Neuroscience Paired associative stimulation Methods medicine Humans Callosal agenesis Evoked Potentials Adult Evoked Potentials Motor Physiology Female Functional Laterality Humans Male Motor Cortex Neural Inhibition Transcranial Magnetic Stimulation Methods Young Adult Interstimulus interval Motor Cortex Neural Inhibition Human brain Evoked Potentials Motor Transcranial Magnetic Stimulation medicine.anatomical_structure Hebbian theory Motor Female Psychology Neuroscience Motor cortex |
| Zdroj: | Cerebral Cortex. 19:907-915 |
| ISSN: | 1460-2199 1047-3211 |
| DOI: | 10.1093/cercor/bhn144 |
| Popis: | This study was designed to examine whether corticocortical paired associative stimulation (cc-PAS) can modulate interhemispheric inhibition (IHI) in the human brain. Twelve healthy right-handed volunteers received 90 paired transcranial stimuli to the right and left primary motor hand area (M1(HAND)) at an interstimulus interval (ISI) of 8 ms. Left-to-right cc-PAS (first pulse given to left M1(HAND)) attenuated left-to-right IHI for one hour after cc-PAS. Left-to-right cc-PAS also increased corticospinal excitability in the conditioned right M1(HAND). These effects were not seen in an asymptomatic individual with callosal agenesis. Additional experiments showed no changes in left-to-right IHI or corticospinal excitability when left-to-right cc-PAS was given at an ISI of 1 ms or at multiple ISIs in random order. At the behavioral level, left-to-right cc-PAS speeded responses with the left but not right index finger during a simple reaction time task. Right-to-left cc-PAS (first pulse given to right M1(HAND)) reduced right-to-left IHI without increasing corticospinal excitability in left M1(HAND). These results provide a proof of principle that cc-PAS can induce associative plasticity in connections between the targeted cortical areas. The efficacy of cc-PAS to induce lasting changes in excitability depends on the exact timing of the stimulus pairs suggesting an underlying Hebbian mechanism. |
| Databáze: | OpenAIRE |
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