Forniceal glioma in children. Clinical article
| Autor: | Thomas Blauwblomme, Hélène Piana, Stéphanie Puget, Nathalie Boddaert, Marie Laure Cuny, Pascale Varlet, Christian Sainte-Rose, John R. Goodden, Virginie Kieffer, Federico DiRocco, Jacques Grill, Thomas Roujeau |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Fornix Brain Ganglioglioma Central nervous system disease Lesion Cohort Studies Child Development Memory Glioma Biopsy medicine Humans Child Retrospective Studies medicine.diagnostic_test Pilocytic astrocytoma business.industry Brain Neoplasms General Medicine medicine.disease Surgery Treatment Outcome El Niño Child Preschool Cohort Educational Status Female medicine.symptom business |
| Zdroj: | Journal of neurosurgery. Pediatrics. 4(3) |
| ISSN: | 1933-0707 |
| Popis: | Object Five to ten percent of pediatric brain tumors are located in the ventricles. Among them, forniceal lesions are rare and their management has not often been described. The aim of this study was to review the clinical, radiological, and histopathological features as well as the feasibility of surgical excision and the outcomes in these patients. Methods From a retrospective analysis of 250 cases of supratentorial pediatric glioma, the records of 8 children presenting with forniceal lesions were selected and reviewed. Results The median age of patients in the cohort was 13.5 years. Presenting features included intracranial hypertension (7 cases), hypothalamic dysfunction (2), and memory dysfunction (3). Complete resection was possible in only 1 case, where the lesion was mainly exophytic; the remaining patients had either a partial resection or biopsy. On histological review, the tumors were confirmed as pilocytic astrocytoma (4 lesions), WHO Grade II astrocytoma (3), and ganglioglioma (1). Postoperatively, working and retrograde memory was normal for all patients, but the authors found a mild alteration in verbal episodic memory in 5 patients. Despite fatigability for 5 patients, academic achievement was normal for all but 2, both of whom had preoperative school difficulties. Additional treatment was required for 5 patients for tumor progression, with a median interval of 19 months from surgery. At a median follow-up duration of 4.9 years, all patients had stable disease. Conclusions In this series, forniceal gliomas were found to be low-grade gliomas. They are surgically challenging, and only exophytic lesions may be cured surgically. Due to the high rate of progression of residual disease, adjuvant therapy is recommended for infiltrative tumors, and it yielded excellent results. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|