Risk factors for coronary heart disease in type 1 diabetic children: the influence of apoE phenotype and glycemic regulation
| Autor: | Tim K. Tso, Jean T. Snook, William B Zipf, Rolando A Lozano |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Blood Glucose
Male Apolipoprotein E medicine.medical_specialty Endocrinology Diabetes and Metabolism Coronary Disease chemistry.chemical_compound Apolipoproteins E Endocrinology Risk Factors Internal medicine Immunopathology Diabetes mellitus Internal Medicine medicine Humans Least-Squares Analysis Risk factor Child Glycemic Glycated Hemoglobin business.industry Cholesterol LDL General Medicine medicine.disease Diabetes Mellitus Type 1 Phenotype chemistry Child Preschool Low-density lipoprotein Female lipids (amino acids peptides and proteins) Analysis of variance Isoelectric Focusing business Lipoprotein |
| Zdroj: | Diabetes Research and Clinical Practice. 54:165-171 |
| ISSN: | 0168-8227 |
| Popis: | The effects of apolipoprotein E (apoE) phenotype and glycemic regulation on plasma levels of lipids and lipoproteins, low density lipoprotein (LDL) composition, LDL particle size, and LDL oxidation were examined in 35 type 1 diabetic children aged 5-12 years. All subjects were classified according to glycemic regulation (HbA(1c)8% vs. HbA(1c)8%). ApoE phenotypes were identified by isoelectric focusing (IEF) followed by immunoblotting. Results from two-way analysis of variance (ANOVA) showed that subjects with apoE 4/3 and HbA(1c)8% had higher concentrations of total cholesterol (TC), LDL-cholesterol (LDL-C), and LDL-cholesterol ester (LDL-CE) than subjects with the same apoE phenotype and HbA(1c)8%. LDL particles in all subjects were classified as the subclass pattern A. Both LDL particle size and susceptibility of LDL to oxidation were not different among subjects stratified by apoE phenotype. In conclusion, children with type 1 diabetes mellitus included in this study did not have high-risk lipoprotein profiles at this early stage of life. However, there was some indication that those with the apoE 4/3 phenotype were more likely to have more favorable lipid profiles when HbA(1c) levels were8%. |
| Databáze: | OpenAIRE |
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