Synthesis and Anti-Oxidant Activity of (5E,9E)-16-(Substituted)-7,8-dihydro-16λ5-dibenzo[d,l][1,3,7,10,2]dioxadiazaphosphacyclotridecine-16-ones
| Autor: | Gangireddy Chandra Sekhar Reddy, Chinta Raveendra Reddy, Kuruva Chandra Sekhar, Chinthaparthi Radha Rani, Chamarthi Naga Raju |
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| Rok vydání: | 2012 |
| Předmět: |
Free Radicals
Hydroxyl Radical Stereochemistry Molecular Conformation Pharmaceutical Science Hydrogen Bonding Stereoisomerism Biological activity Free Radical Scavengers Anti oxidant Ring (chemistry) Medicinal chemistry Structure-Activity Relationship chemistry.chemical_compound Organophosphorus Compounds chemistry Thiadiazoles Drug Discovery Nitro Mass spectrum Spectral data Triethylamine |
| Zdroj: | Archiv der Pharmazie. 345:495-502 |
| ISSN: | 0365-6233 |
| Popis: | A new class of biologically active 13-membered phosphorus-macroheterocycles (6a-l) were conveniently synthesized from 1,2-bis(salicylidene amino)-phenylene (1), by treating with phosporusoxychloride (3) and followed by reacting with various aromatic thiols and amines (5f-l) in one path, and in another path 1 was directly treated with various phosphorodichloridates (2a-e) in the presence of triethylamine at 0-10°C under N(2) atmosphere in THF. All the title compounds were confirmed by analytical and spectral data (IR, (1) H-, (13) C-, (31) P-NMR, and mass spectra) and screened for anti-oxidant activity. Among these compounds, 6k, 6e, and 6l containing nitro, fluoro, and chloro groups as substituents on the phenyl ring exhibited high anti-oxidant activity with effective inhibitory concentration (IC(50) ) values. |
| Databáze: | OpenAIRE |
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