Improving Structure Delineation for Radiation Therapy Planning Using Dual-Energy CT
| Autor: | G. Noid, Diane Schott, Christopher J. Schultz, Eric S. Paulson, X. Allen Li, Justin Zhu, D.E. Prah, Nilesh Mistry, An Tai |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research Materials science medicine.medical_treatment motion artifacts dual-energy CT radiation therapy lcsh:RC254-282 Meningioma 03 medical and health sciences 0302 clinical medicine image contrast Hounsfield scale medicine Radiation treatment planning Image resolution Original Research business.industry Digital Enhanced Cordless Telecommunications Soft tissue radiation oncology medicine.disease metal artifacts lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens photon starvation Radiation therapy 030104 developmental biology Oncology 030220 oncology & carcinogenesis mono-energetic image Dual energy ct Nuclear medicine business |
| Zdroj: | Frontiers in Oncology, Vol 10 (2020) Frontiers in Oncology |
| DOI: | 10.3389/fonc.2020.01694/full |
| Popis: | Purpose We present the advantages of using dual-energy CT (DECT) for radiation therapy (RT) planning based on our clinical experience. Methods DECT data acquired for 20 representative patients of different tumor sites and/or clinical situations with dual-source simultaneous scanning (Drive, Siemens) and single-source sequential scanning (Definition, Siemens) using 80 and 140-kVp X-ray beams were analyzed. The data were used to derive iodine maps, fat maps, and mono-energetic images (MEIs) from 40 to 190 keV to exploit the energy dependence of X-ray attenuation. The advantages of using these DECT-derived images for RT planning were investigated. Results When comparing 40 keV MEIs to conventional 120-kVp CT, soft tissue contrast between the duodenum and pancreatic head was enhanced by a factor of 2.8. For a cholangiocarcinoma patient, contrast between tumor and surrounding tissue was increased by 96 HU and contrast-to-noise ratio was increased by up to 60% for 40 keV MEIs compared to conventional CT. Simultaneous dual-source DECT also preserved spatial resolution in comparison to sequential DECT as evidenced by the identification of vasculature in a pancreas patient. Volume of artifacts for five patients with titanium implants was reduced by over 95% for 190 keV MEIs compared to 120-kVp CT images. A 367-cm3 region of photon starvation was identified by low CT numbers in the soft tissue of a mantle patient in a conventional CT scan but was eliminated in a 190 keV MEI. Fat maps enhanced image contrast as demonstrated by a meningioma patient. Conclusion The use of DECT for RT simulation offers clinically meaningful advantages through improved simulation workflow and enhanced structure delineation for RT planning. |
| Databáze: | OpenAIRE |
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