Reproducibility of dental caries in Balb/c mice induced by the bacterium Streptococcus mutans
| Autor: | J.Huis in 't Veld, Elbarte M. Kamp, Janita Drost, W. H. van Palenstein Helderman, O. Backer Dirks |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Male
Serotype Sucrose Smooth surface caries Dental Caries Biology Microbiology BALB/c Diet Cariogenic Streptococcus mutans Mice stomatognathic system Streptococcal Infections Animals General Dentistry Mice Inbred BALB C Experimental model Cell Biology General Medicine biology.organism_classification Disease Models Animal stomatognathic diseases Otorhinolaryngology Female Bacteria |
| Zdroj: | Archives of Oral Biology. 28:153-158 |
| ISSN: | 0003-9969 |
| DOI: | 10.1016/0003-9969(83)90122-x |
| Popis: | Dental caries induced by infection with Strep. mutans C67-1 (serotype c) or Strep. mutans 50B4 (serotype d/g) and feeding a 30 per cent sucrose-containing diet was found mainly in fissures; smooth surface caries was not detected. A decrease in the mean caries score was observed with time, coinciding with lower recoveries of Strep. mutans at the end of the experimental period. The decrease in caries formation may be attributed to changes in some of the cariogenic properties of the individual Strep. mutans strains during maintenance in the laboratory, as re-isolation of the strains from caries-active mice yielded similar and reproducible caries scores to those in early experiments. Hence Balb/c mice can be used as an experimental model in caries research, provided that great care is taken in selecting and storing the bacteria. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|