Mab21, the mouse homolog of a C. elegans cell-fate specification gene, participates in cerebellar, midbrain and eye development
| Autor: | Anna Corradi, Danila Baldessari, Ombretta Pozzoli, Riccardo Fesce, Nicoletta Malgaretti, G. Giacomo Consalez, Salvador Martinez, Edoardo Boncinelli, Margherita Mariani |
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| Přispěvatelé: | Mariani, M, Corradi, A, Baldessari, D, Malgaretti, N, Pozzoli, O, Fesce, R, Martinez, S, Boncinelli, E, Consalez, GIAN GIACOMO |
| Jazyk: | angličtina |
| Rok vydání: | 1998 |
| Předmět: |
Embryology
Cerebellum Central nervous system Cell fate determination Biology Eye Retina Mice Mesencephalon medicine Animals Caenorhabditis elegans Proteins Gene Regulator gene Homeodomain Proteins Genetics Gene Expression Regulation Developmental Helminth Proteins Embryo Mammalian medicine.anatomical_structure Animals Newborn Eye development Homeobox PAX6 Developmental Biology |
| Popis: | A multitude of regulatory genes are involved in phylogenetically conserved developmental cascades required for the patterning, cell-type specification, and differentiation of specific central nervous system (CNS) structures. Here, we describe the distribution of a mouse transcript encoding a homolog of the C. elegans mab-21 gene. In the nematode tail, mab-21 is required for the short-range patterning and cell-fate determination events mediated by egl-5 and mab-18, two homeobox genes homologous to Abd-B and Pax6, respectively. In mouse midgestation embryogenesis, Mab21 is expressed at its highest levels in the rhombencephalon, cerebellum, midbrain, and prospective neural retina. Our data and the genetic interactions previously documented in the nematode suggest that Mab21 may represent a novel, important regulator of mammalian cerebellum and eye development. |
| Databáze: | OpenAIRE |
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