Aztreonam in the Treatment of Bacterial Meningitis
| Autor: | L.M.J. Mimica, M.D.V. Martino, T.M. Milstein-Kuschnaroff, R. Lorenco, S. Maassen, S.P. Barbosa, N.J.F. Cavalcante, I.M. Mimica, P.A. Ayroza-Galvão |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Male
medicine.medical_specialty Dose Aztreonam medicine.disease_cause Asymptomatic Gastroenterology Haemophilus influenzae chemistry.chemical_compound Internal medicine Drug Discovery Humans Medicine Monobactam Meningitis Pharmacology (medical) Subdural effusion Meningitis Haemophilus Pharmacology business.industry Infant Bacterial Infections General Medicine medicine.disease Hydrocephalus Surgery Infectious Diseases Oncology chemistry Child Preschool Salmonella Infections Female medicine.symptom business medicine.drug |
| Zdroj: | Chemotherapy. 35:39-44 |
| ISSN: | 1421-9794 0009-3157 |
| Popis: | The monobactam aztreonam was used to treat 22 young patients with meningitis caused by gram-negative bacilli. Haemophilus influenzae was isolated from the CSF of 21 patients and Salmonella heidelberg from the CSF of 1. Dosages ranged from 100 to 200 mg/kg/day in 4 doses at 6-hour intervals. Minimal inhibitory concentrations were determined by the broth dilution method for all isolated strains, and values ranged from 0.05 to 2.0 micrograms/ml. Blood and CSF drug levels were determined by a microbiologic plate diffusion method, and mean values for CSF and blood were 1.4 and 14.9 micrograms/ml, respectively. The outcome was good in 21 patients; 1 patient died. Complications were mild; subdural effusion occurred in 6 cases and was managed clinically; asymptomatic hydrocephalus was seen in 4; seizure during the acute phase occurred in 6 cases; hypoacusis was noted in 2, and motor impairment was detected at the follow-up in 1 case. Aztreonam achieved good blood and CSF penetration and performed well in the treatment of 20 cases of H. influenzae meningitis and in the one case of S. heidelberg meningitis. |
| Databáze: | OpenAIRE |
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