Synthesis and application of hypercrosslinked polymers with weak cation-exchange character for the selective extraction of basic pharmaceuticals from complex environmental water samples
| Autor: | David C. Sherrington, Dominika Bratkowska, Núria Fontanals, Peter A. G. Cormack, F. Borrull, Rosa Maria Marcé |
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| Rok vydání: | 2010 |
| Předmět: |
chemistry.chemical_classification
Sorbent Chromatography Polymers Carboxylic acid Comonomer Solid Phase Extraction Organic Chemistry Extraction (chemistry) General Medicine Polymer Biochemistry Analytical Chemistry chemistry.chemical_compound Cross-Linking Reagents Pharmaceutical Preparations Methacrylic acid chemistry Specific surface area QD Adsorption Cation Exchange Resins Solid phase extraction Particle Size Water Pollutants Chemical |
| Zdroj: | Journal of Chromatography A. 1217:1575-1582 |
| ISSN: | 0021-9673 |
| DOI: | 10.1016/j.chroma.2010.01.037 |
| Popis: | The synthesis of high specific surface area sorbents (HXLPP-WCX) in the form of hypercrosslinked polymer microspheres with narrow particle size distributions, average particle diameters around 6 μm, and weak cation-exchange (WCX) character, is described. The WCX character arises from carboxylic acid moieties in the polymers, derived from the comonomer methacrylic acid. A novel HXLPP-WCX sorbent with an attractive set of chemical and physical properties was then used in an off-line solid-phase extraction (SPE) protocol for the selective extraction of a group of basic compounds from complex environmental samples, a priority being the clean separation of the basic compounds of interest from acidic compounds and interferences. The separation power of the new sorbent for basic pharmaceuticals was compared to two commercially available, mixed-mode sorbents, namely Oasis WCX and Strata-X-CW. Under identical experimental conditions, HXLPP-WCX was found to deliver both higher capacity and better selectivity in SPE than either of the two commercially available materials. In an optimised SPE protocol, the HXLPP-WCX sorbent gave rise to quantitative and selective extractions of low μg l−1 levels of basic pharmaceuticals present in 500 ml of river water and 250 ml of effluent waste water. |
| Databáze: | OpenAIRE |
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