Gadolinium dose optimisation in patients with multiple sclerosis: intra- and inter-individual comparisons
| Autor: | Alessandro Stecco, Elena Migazzo, Alessandro Carriero, Fabiana Tesser, Tommaso Scarabino, Antonio Saponaro, Francesco Monaco |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Gadolinium DTPA Male Multiple Sclerosis Wilcoxon signed-rank test Gadolinium chemistry.chemical_element Contrast Media Statistics Nonparametric Injections Central nervous system disease medicine Humans Radiology Nuclear Medicine and imaging In patient Child medicine.diagnostic_test business.industry Multiple sclerosis Magnetic resonance imaging General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging Contrast medium chemistry Female Bolus (digestion) business Nuclear medicine |
| Zdroj: | European journal of radiology. 57(1) |
| ISSN: | 0720-048X |
| Popis: | Objective To assess the efficacy of single, double and triple doses of 1M gadolinium in the magnetic resonance (MR) evaluation of multiple sclerosis (MS) lesions in order to establish the best trade-off in terms of dose and number of injections. Materials and methods Twenty-three patients with relapsing remitting or secondary progressive MS underwent MR scans of the brain, spine or both. Signal intensity, the number of enhancing lesions and the areas of MS plaque were measured in T1-weighted images before and after single, double or triple doses of contrast medium. Wilcoxon's two-sample test and the Mann–Whitney U -test were used to evaluate the differences between the groups, and between doses in the same patient. Results There was no significant difference in area signal intensity or the number of enhancing lesions between the group examined after a single injection of double-dose (DD) contrast medium and the group examined after multiple injections of a triple dose (TD). The difference in the areas of enhancement and signal intensity between a single dose (SD) and TD significantly increased after the second bolus. Conclusion Gadolinium injections in MS patients can be optimised by giving a single DD bolus, which leads to the same results as a TD administered as two boli. |
| Databáze: | OpenAIRE |
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