Platelet microvesicles are associated with the severity of coronary artery disease: comparison between peripheral and coronary circulation
| Autor: | Efthalia Yiannaki, Eugene Gkaliagkousi, I. Vasileiadis, P. Dolgyras, Ippokratis Zarifis, Eleni Gavriilaki, Stella Douma, Dimitra Markala, Savas Grigoriadis, Barbara Nikolaidou, Panagiota Anyfanti, Antonios Lazaridis, Areti Triantafyllou |
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| Rok vydání: | 2020 |
| Předmět: |
Blood Platelets
Acute coronary syndrome medicine.medical_specialty Population Femoral artery Coronary Artery Disease 030204 cardiovascular system & hematology Coronary artery disease 03 medical and health sciences Coronary circulation 0302 clinical medicine Left coronary artery Cell-Derived Microparticles medicine.artery Internal medicine Coronary Circulation Medicine Humans Platelet 030212 general & internal medicine Acute Coronary Syndrome education education.field_of_study business.industry Thrombosis Hematology medicine.disease medicine.anatomical_structure Cardiology Cardiology and Cardiovascular Medicine business Biomarkers |
| Zdroj: | Journal of thrombosis and thrombolysis. 51(4) |
| ISSN: | 1573-742X |
| Popis: | Microvesicles (MVs) have recently emerged as markers of thrombosis. Furthermore, there is an unexplained residual thrombotic risk is observed in patients with acute coronary syndrome (ACS) and/or stable coronary artery disease (CAD), despite treatment. We measured platelet (PMVs) and erythrocyte (ErMVs) in patients with ACS and stable CAD, both in the peripheral and coronary circulation. We studied consecutive eligible patients during a coronary angiography. Blood samples were collected from the stem of the left coronary artery and femoral artery. PMVs were significantly increased in CAD patients compared to controls. ACS patients had also increased PMVs in coronary and peripheral circulation, compared to controls. Furthermore, ACS patients exhibited increased PMVs in coronary compared to peripheral circulation. Lastly, coronary PMVs were associated with the severity of CAD based on the SYNTAX score. No significant differences were observed in the levels of ErMVs among groups. Therefore, PMVs emerge as novel markers of thrombosis in CAD, further augmenting the vicious cycle of inflammation and thrombosis during ACS. Importantly, coronary PMVs may reflect the severity of CAD in this population. |
| Databáze: | OpenAIRE |
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