Effect of crystallinity on the percutaneous absorption of corticosteroid. I. Determination of the degree of crystallinity of hydrocortisone acetate in ground mixtures with crystalline cellulose
| Autor: | Katsuo Kataoka, Sadao Hirota, Kouji Kinuno, Masami Morita |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Hydrocortisone
medicine.drug_class Chemistry Skin Absorption General Chemistry General Medicine eye diseases Amorphous solid Crystallinity chemistry.chemical_compound Drug Discovery X-ray crystallography Percutaneous absorption medicine Corticosteroid Organic chemistry sense organs Cellulose Crystallization Dissolution Hydrocortisone acetate Nuclear chemistry |
| Zdroj: | Chemicalpharmaceutical bulletin. 33(2) |
| ISSN: | 0009-2363 |
| Popis: | The effect of the crystallinity of a topically applied drug on its percutaneous absorption was investigated with hydrocortisone acetate as a model drug. To decrease the degree of crystallinity, the drug was ground with crystalline cellulose. The X-ray diffraction method for determining the degree of crystallinity was shown to be valid in the range of amorphous cellulose ratio of 0 to ca. 50% by using simple mixtures of glutathione and amorphous cellulose. Thus, the dissolution rate of hydrocortisone acetate was confirmed to increase quantitatively with decreasing crystallinity. |
| Databáze: | OpenAIRE |
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