Simple noninvasive measurement of skin autofluorescence

Autor: Meerwaldt, R, Links, T, Graaff, R, Thorpe, SR, Baynes, JW, Hartog, J, Gans, R, Smit, Andries, Monnier, VM, Ames, JM, Thorpe
Přispěvatelé: Damage and Repair in Cancer Development and Cancer Treatment (DARE), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Lifestyle Medicine (LM), Groningen Kidney Center (GKC), Vascular Ageing Programme (VAP)
Rok vydání: 2005
Předmět:
Glycation End Products
Advanced
medicine.medical_specialty
Pathology
NEPHROPATHY
Blood sugar
Renal function
DEPENDENT DIABETES-MELLITUS
autofluorescence
AMINOGUANIDINE
Arginine
General Biochemistry
Genetics and Molecular Biology
DISEASE
Nephropathy
chemistry.chemical_compound
History and Philosophy of Science
Reference Values
Internal medicine
Diabetes mellitus
noninvasive
medicine
Diabetes Mellitus
Humans
Pentosidine
OXIDATIVE STRESS
FLUORESCENCE
Kidney transplantation
ACCUMULATION
Skin
Glycated Hemoglobin
COMPLICATIONS
medicine.diagnostic_test
diabetes
business.industry
General Neuroscience
advanced glycation end products
Lysine
GLYCOXIDATION
medicine.disease
Autofluorescence
Endocrinology
Spectrometry
Fluorescence
chemistry
Creatinine
Skin biopsy
Regression Analysis
business
GLYCATION END-PRODUCTS
Zdroj: MAILLARD REACTION: CHEMISTRY AT THE INTERFACE OF NUTRITION, AGING, AND DISEASE, 290-298
STARTPAGE=290;ENDPAGE=298;TITLE=MAILLARD REACTION: CHEMISTRY AT THE INTERFACE OF NUTRITION, AGING, AND DISEASE
ISSN: 0077-8923
Popis: Accumulation of advanced glycation end products (AGEs) is thought to play a role in the pathogenesis of chronic complications of diabetes mellitus and renal failure. Several studies indicate that AGE accumulation in tissue may reflect the cumulative effect of hyperglycemia and oxidative stress over many years. Simple quantitation of AGE accumulation in tissue could provide a tool for assessing the risk of long-term complications. Because several AGEs exhibit autofluoreseence, we developed a noninvasive autofluorescence reader (AFR). Skin autofluorescence measured with the AFR correlates with collagen-linked fluorescence and specific skin AGE levels from skin biopsy samples. Furthermore, skin autofluorescence correlates with long-term glycemic control and renal function, and preliminary results show correlations with the presence of long-term complications in diabetes. The AFR may be useful as a clinical tool for rapid assessment of risk for AGE-related long-term complications in diabetes and in other conditions associated with AGE accumulation.
Databáze: OpenAIRE
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