Histogram analysis of apparent diffusion coefficients after neoadjuvant chemotherapy in breast cancer
| Autor: | Sung Hun Kim, Bong Joo Kang, Yun Ju Kim, Min Sun Jin, Ahwon Lee, Byung Joo Song |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Oncology medicine.medical_specialty Percentile medicine.medical_treatment Antineoplastic Agents Breast Neoplasms 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine medicine Humans Effective diffusion coefficient Radiology Nuclear Medicine and imaging Neoadjuvant therapy Aged Neoplasm Staging Retrospective Studies Chemotherapy medicine.diagnostic_test business.industry Magnetic resonance imaging Middle Aged medicine.disease Neoadjuvant Therapy body regions Radiation therapy Diffusion Magnetic Resonance Imaging Treatment Outcome 030220 oncology & carcinogenesis Kurtosis Female business Nuclear medicine |
| Zdroj: | Japanese Journal of Radiology. 34:657-666 |
| ISSN: | 1867-108X 1867-1071 |
| Popis: | To evaluate the changes in the apparent diffusion coefficient (ADC) histogram during neoadjuvant chemotherapy (NAC) for breast cancer, and to compare the observed changes in pathologically verified responders and non-responders. Sixty-two patients received NAC followed by surgery. Responders were defined by a tumor cell reduction of at least 30 % using the Miller–Payne grading system. All the patients underwent 3T magnetic resonance with diffusion-weighted imaging (b values of 0 and 750 s/mm2) before the NAC and after the completion of two cycles of NAC. Mean, minimum, 10th, 25th, 50th, and 75th percentile of ADCs significantly increased after NAC and maximum ADC significantly decreased. Skewness became less positive and kurtosis decreased. A tendential, although not statistically significant, higher increase in mean, minimum, 10th, 25th, 50th, 75th, and 90th percentiles of ADCs was observed in responders in comparison with non-responders. ADC histogram analysis quantitatively demonstrates the alterations during the treatment course. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink