Tris(2-butoxyethyl) phosphate (TBEP): A flame retardant in solid waste display hepatotoxic and carcinogenic risks for humans

Autor:	Quaiser Saquib, Abdullah M. Al-Salem, Maqsood A. Siddiqui, Sabiha M. Ansari, Xiaowei Zhang, Abdulaziz A. Al-Khedhairy
Rok vydání:	2021
Předmět:	Environmental Engineering Health Toxicology and Mutagenesis Public Health Environmental and Occupational Health General Medicine General Chemistry Solid Waste Pollution Organophosphates Phosphates Organophosphorus Compounds Carcinogens Environmental Chemistry Humans Flame Retardants
Zdroj:	Chemosphere. 296
ISSN:	1879-1298
Popis:	Recent reports have confirmed that tris(2-butoxyethyl) phosphate (TBEP), an organophosphorous flame retardants (OPFRs), profoundly detected in the dust from solid waste (SW), e-waste dumping sites, landfills, and wastewater treatment facilities. Herein, we evaluated the hepatotoxic and carcinogenic potential of TBEP in human liver cells (HepG2). HepG2 cells exhibited cytotoxicity after 3 days of exposure, especially at greater concentrations (100-400 μM). TBEP induced severe DNA damage and cell cycle disturbances that trigger apoptosis in HepG2. TBEP treated cells showed an elevated level of esterase, nitric oxide (NO), reactive oxygen species (ROS), and influx of Ca
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::482d2bd8c903373dafc95b768af58841 https://pubmed.ncbi.nlm.nih.gov/35216979 Zobrazit plný text záznamu Full Text from ScienceDirect