Follow-up study in local allergic rhinitis shows a consistent entity not evolving to systemic allergic rhinitis
| Autor: | Gabriela Canto, Jean-Louis Guéant, María José Torres, Miguel Blanca, Rocio Herrera, Maria Angeles Zambonino, Paloma Campo, Lidia Melendez, Rosa-Maria Guéant-Rodriguez, Carmen Rondon, Natalia Blanca-López |
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| Přispěvatelé: | Allergy Service [Carlos Haya Hospital], Hospital Regional Universitario Carlos Haya, Allergy Service [Hospital Universitario Infanta Leonor], Hospital Universitario Infanta Leonor [Madrid], Research Laboratory [Carlos Haya Hospital], Hospital Regional Universitario Carlos Haya-Fundacion Imabis, Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Faculté de Médecine [Nancy], Université de Lorraine (UL) |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Hypersensitivity
Immediate Male [SDV]Life Sciences [q-bio] Provocation test medicine.disease_cause Immunoglobulin E Allergic rhinitis Atopy 0302 clinical medicine Allergen Risk Factors Immunology and Allergy Medicine 030223 otorhinolaryngology education.field_of_study biology Middle Aged 3. Good health natural history local allergic rhinitis Female Adult medicine.medical_specialty Rhinitis Allergic Perennial Adolescent Immunology Population 03 medical and health sciences Young Adult Nonallergic rhinitis Humans education Asthma Skin Tests business.industry nasal allergen provocation test Aeroallergen Allergens medicine.disease Dermatology Rhinitis Allergic systemic atopy 030228 respiratory system Case-Control Studies biology.protein business Follow-Up Studies |
| Zdroj: | Journal of Allergy and Clinical Immunology Journal of Allergy and Clinical Immunology, Elsevier, 2014, 133 (4), pp.1026-1031. ⟨10.1016/j.jaci.2013.10.034⟩ |
| ISSN: | 0091-6749 |
| DOI: | 10.1016/j.jaci.2013.10.034⟩ |
| Popis: | International audience; BackgroundLocal allergic rhinitis (LAR) is a common disease that affects 25.7% of the rhinitis population and more than 47% of patients previously diagnosed with nonallergic rhinitis. Whether LAR is the first step in the natural history of allergic rhinitis (AR) with systemic atopy or a consistent entity is unknown.ObjectiveThe aim was to evaluate the natural history of a population with LAR of recent onset and the development of AR and asthma.MethodsA prospective 10-year follow-up study with initial cohorts of 194 patients with LAR of recent onset and 130 healthy controls is being undertaken. A clinical-demographic questionnaire, spirometry, skin prick test, and specific IgE to aeroallergens were done yearly. Nasal allergen provocation tests with Dermatophagoides pteronyssinus, Alternaria alternata, Olea europea, and a mix of grass pollen were performed at baseline and after 5 years.ResultsAt disease onset, most of the patients with LAR had moderate-to-severe persistent-perennial rhinitis; conjunctivitis and asthma were the main comorbidities (51.1% and 18.8%, respectively), and D pteronyssinus was the most relevant aeroallergen (51.1%). After 5 years of follow-up, a worsening of rhinitis was detected in 26.2%, with an increase in symptom persistence and severity, and new associations with conjunctivitis and asthma. Atopy was detected by skin prick test and/or serum specific-IgE in patients with LAR (6.81%) and in controls (4.5%).ConclusionsThis study shows a similar rate of development of systemic atopy in LAR and controls, which suggests that LAR is an entity well differentiated from AR. To determine the natural course of LAR more precisely, this study is in progress to complete 10 years of follow-up. |
| Databáze: | OpenAIRE |
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