Endogenous Fluorescence Lifetime Imaging (FLIM) Endoscopy For Early Detection Of Oral Cancer And Dysplasia
| Autor: | Yi-Shing Lisa Cheng, Elvis Duran-Sierra, Javier A. Jo, Kristen C. Maitland, John Wright, Shuna Cheng, Terry Reese, Beena Ahmed, Bilal H. Malik, Rodrigo Cuenca-Martinez |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Fluorescence-lifetime imaging microscopy Pilot Projects Fluorescence 03 medical and health sciences 0302 clinical medicine Biopsy medicine Humans Stage (cooking) Early Detection of Cancer Oral Dysplasia medicine.diagnostic_test business.industry Optical Imaging Cancer Endoscopy 030206 dentistry medicine.disease Autofluorescence Dysplasia 030220 oncology & carcinogenesis Mouth Neoplasms Radiology business |
| Zdroj: | EMBC |
| DOI: | 10.1109/embc.2018.8513027 |
| Popis: | We have performed a pilot clinical study, in which multispectral endogenous fluorescence (or autofluorescence) lifetime imaging (FLIM) was performed on clinically suspicious oral lesions of 73 patients undergoing tissue biopsy for oral dysplasia and cancer diagnosis. The results from this pilot study indicated that mild-dysplasia and early stage oral cancer could be detected from benign lesions using a computed aided diagnosis system developed based on biochemical and metabolic biomarkers derived from the endogenous FLIM images. The diagnostic performance of this novel FLIM clinical tool was estimated using a leave-onepatient-out cross-validation approach, which reported levels of sensitivity >90%, specificity >85%, and Area Under the Receiving Operating Curve (ROC-AUC) >0.9. |
| Databáze: | OpenAIRE |
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