Clinical determinants of the PR interval duration in Swiss middle‐aged adults: The CoLaus/PsyCoLaus study
| Autor: | Federica Bocchi, Jürg Schläpfer, Peter Vollenweider, Marylène Bay, Etienne Pruvot, Pedro Marques-Vidal |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male PR interval duration Aging medicine.medical_specialty Population Clinical Investigations electrocardiogram 030204 cardiovascular system & hematology PR interval Switzerland adults cross-sectional determinants Electrocardiography 03 medical and health sciences 0302 clinical medicine Heart Rate Risk Factors Internal medicine Humans Medicine Prospective Studies 030212 general & internal medicine education Aged education.field_of_study Troponin T business.industry Incidence Magnesemia Arrhythmias Cardiac General Medicine Odds ratio Middle Aged Stepwise regression Confidence interval Cross-Sectional Studies Cardiology Female cross‐sectional Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | Clinical Cardiology Clinical cardiology, vol. 43, no. 6, pp. 614-621 |
| ISSN: | 1932-8737 0160-9289 |
| DOI: | 10.1002/clc.23356 |
| Popis: | Background Prolonged PR interval (PRi) is associated with adverse outcomes. However, PRi determinants are poorly known. We aimed to identify the clinical determinants of the PRi duration in the general population. Hypothesis Some clinical data are associated with prolonged PRi. Methods Cross‐sectional study conducted between 2014 and 2017. Electrocardiogram‐derived PRi duration was categorized into normal or prolonged (>200 ms). Determinants were identified using stepwise logistic regression, and results were expressed as multivariable‐adjusted odds ratio (OR) (95% confidence interval). A further analysis was performed adjusting for antiarrhythmic drugs, P‐wave contribution to PRi duration, electrolytes (kalemia, calcemia, and magnesemia), and history of cardiovascular disease. Results Overall, 3655 participants with measurable PRi duration were included (55.6% females; mean age 62 ± 10 years), and 330 (9.0%) had prolonged PRi. Stepwise logistic regression identified male sex (OR 1.41 [1.02‐1.97]); aging (65‐74 years: OR 2.29 [1.61‐3.24], and ≥ 75 years: OR 4.21 [2.81‐6.31]); increased height (per 5 cm, OR 1.15 [1.06‐1.25]); hypertension (OR 1.37 [1.06‐1.77]); and hs troponin T (OR 1.67 [1.15‐2.43]) as significantly and positively associated, and high resting heart rate (≥70 beats/min, OR 0.43 [0.29‐0.62]) as negatively associated with prolonged PRi. After further adjustment, male sex, aging and increased height remained positively, and high resting heart rate negatively associated with prolonged PRi. Hypertension and hs troponin T were no longer associated. Conclusion In a sample of the Swiss middle‐aged population, male sex, aging and increased height significantly increased the likelihood of a prolonged PRi duration, whereas a high resting heart rate decreased it. |
| Databáze: | OpenAIRE |
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