Effect of nitric oxide synthase inhibition on regional blood flow during hyperthermia
| Autor: | Candace B. Matthew, P. C. Szlyk-Modrow, IV Iv Sils, K. A. Tartarini, R. P. Francesconi |
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| Rok vydání: | 2000 |
| Předmět: |
Hyperthermia
medicine.medical_specialty Circulatory collapse Physiology Chemistry Heatstroke medicine.disease Biochemistry Nitric oxide chemistry.chemical_compound Endocrinology Blood pressure Anesthesia Internal medicine Heart rate medicine medicine.symptom General Agricultural and Biological Sciences Splanchnic Vasoconstriction Developmental Biology |
| Zdroj: | Journal of thermal biology. 26(1) |
| ISSN: | 0306-4565 |
| Popis: | The loss of compensatory splanchnic vasoconstriction during hyperthermia was assessed in rats after administration of either 0, 10, 30, or 100mg/kg N(w)-nitro-L-arginine methyl ester,L-NAME. Rectal temperature (T(re)), heart rate (HR), mean arterial blood pressure (MAP), breathing frequency (BF), and renal, mesenteric and caudal blood flows (Q(R), Q(M) and Q(C)) were measured until irreversible cardiovascular collapse occurred. HR, MAP and BF increased as T(re) rose to 42 degrees C, then fell as circulatory collapse occurred. As dose increased T(re) at collapse decreased. Q(M) decreased until a T(re) of 41.5-42 degrees C and then increased. Q(R) and Q(C) were unaffected by either hyperthermia orL-NAME. Inhibition of NO synthase did not prevent the circulatory collapse of heatstroke; the higher doses ofL-NAME may have exacerbated the onset of circulatory failure. |
| Databáze: | OpenAIRE |
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