Autophagy, Myocardial Protection, and the Metabolic Syndrome
| Autor: | Robert M. Mentzer, Zoltán Giricz, Roberta A. Gottlieb |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Ischemia Myocardial Reperfusion Injury Article Stress Physiological Internal medicine Autophagy Animals Humans Medicine Ventricular remodeling Metabolic Syndrome Pharmacology Cardioprotection Ventricular Remodeling business.industry Myocardium medicine.disease Cell biology Ischemic Preconditioning Myocardial Cardiology Ischemic preconditioning Cellular energy Metabolic syndrome Energy Metabolism Cardiology and Cardiovascular Medicine business Homeostasis |
| Zdroj: | Journal of Cardiovascular Pharmacology. 60:125-132 |
| ISSN: | 0160-2446 |
| Popis: | Autophagy is a housekeeping process which helps to maintain cellular energy homeostasis and remove damaged organelles. In the heart, autophagy is an adaptive process that is activated in response to stress including acute and chronic ischemia. Given the evidence that autophagy is suppressed in energy-rich conditions, the objective of this review is to examine autophagy and cardioprotection in the setting of the metabolic syndrome. Clinical approaches that involve the induction of cardiac autophagy pharmacologically to enhance the heart’s tolerance to ischemia are also discussed. |
| Databáze: | OpenAIRE |
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