Androgen-replacement therapy depresses the ex vivo production of inflammatory cytokines by circulating antigen-presenting cells in aging type-2 diabetic men with partial androgen deficiency
| Autor: | J. J. Corrales, M T Mories, A. Orfao, J M Miralles, M Almeida, R.M. Burgo |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Hormone Replacement Therapy medicine.drug_class Endocrinology Diabetes and Metabolism medicine.medical_treatment Anti-Inflammatory Agents Antigen-Presenting Cells Plasmacytoid dendritic cell Statistics Nonparametric Proinflammatory cytokine Endocrinology Internal medicine Androgen deficiency medicine Humans Testosterone Lymphocyte Count Lymphocytes Aged Interleukin-6 Tumor Necrosis Factor-alpha business.industry Interleukin Middle Aged medicine.disease Androgen Lymphocyte Subsets Diabetes Mellitus Type 2 Androgen Therapy Case-Control Studies Depression Chemical Immunology Androgens Cytokines Tumor necrosis factor alpha Androgen replacement therapy business Interleukin-1 |
| Zdroj: | Journal of Endocrinology. 189:595-604 |
| ISSN: | 1479-6805 0022-0795 |
| DOI: | 10.1677/joe.1.06779 |
| Popis: | Androgens are considered to have immunomodulatory effects but their cellular mechanisms of action remain largely unknown. In the present study we prospectively analyzed the serial effects of androgen-replacement therapy on both the distribution of peripheral blood lymphocytes, monocytes and dendritic cells as well as on the production of interleukin (IL)-1β, IL-6 and tumor necrosis factor α (TNFα) inflammatory cytokines by circulating monocytes and CD33 myeloid, CD16 and plasmacytoid dendritic cell subsets, the most potent antigen-presenting cells (APCs) in type-2 diabetic men with partial androgen deficiency. Analyses were performed before therapy and at 1, 3, 6 and 12 months after treatment with 150 mg testosterone enanthate every 2 weeks in a group of 13 type-2 diabetic men. Our results show for the first time that testosterone-replacement therapy is associated with a reduction or complete abrogation of spontaneous ex vivo production of IL-1β, IL-6 and TNFα by APCs. Meanwhile, the in vitro production of inflammatory cytokines by these cells after stimulation with lipopolysaccharide plus recombinant human interferon-γ remained unchanged, suggesting that APCs preserve their constitutive machinery to produce inflammatory cytokines under androgen treatment. These results confirm and extend previous observations about the anti-inflammatory effects of androgen therapy on APCs in a new, previously unexplored model of androgen deficiency; namely, aging type-2 diabetic men. A decreased production of inflammatory cytokines by APCs might have important consequences for sex differences in susceptibility to autoimmune diseases, inflammatory response to injury and atheromatosis. |
| Databáze: | OpenAIRE |
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