Supplementary figures and figure legends from Ku80-Targeted pH-Sensitive Peptide–PNA Conjugates Are Tumor Selective and Sensitize Cancer Cells to Ionizing Radiation

Autor: Peter M. Glazer, Donald M. Engelman, Raman Bahal, Stanley Oyaghire, Yanfeng Liu, Ha Pham, Alanna R. Kaplan
Rok vydání: 2023
Popis: Fig. S1: pHLIP-αKu80(γ) binds to the mouse Ku80 sequence. Fig. S2: Validation of tumor vs. stromal cell sorting in EMT6-GFP cells. Fig. S3: Partial suppression of Ku80 expression induces radiosensitivity in cultured cancer cells. Fig. S4: pHLIP-αKu80(γ) causes tumor radiosensitization. Fig. S5: pHLIP-αKu80(γ) causes in vitro radiosensitization. Fig. S6: pHLIP-αKu80(γ) does not induce electrolyte abnormalities. Fig. S7: pHLIP-αKu80(γ) does not cause bone marrow suppression.
Databáze: OpenAIRE