Effect of Ambient Air Pollution on Pulmonary Exacerbations and Lung Function in Cystic Fibrosis
| Autor: | Stacey A. Newsom, Lianne Sheppard, Christopher H. Goss, Jonathan S. Schildcrout, Joel D. Kaufman |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Risk Pulmonary and Respiratory Medicine medicine.medical_specialty Adolescent Cystic Fibrosis Critical Care and Intensive Care Medicine Cystic fibrosis Cohort Studies Forced Expiratory Volume Statistical significance Internal medicine Intensive care Pulmonary fibrosis medicine Humans Child Respiratory Tract Infections Air Pollutants business.industry Respiratory disease Confounding medicine.disease United States Confidence interval Surgery Multivariate Analysis Linear Models Female business Cohort study |
| Zdroj: | American Journal of Respiratory and Critical Care Medicine. 169:816-821 |
| ISSN: | 1535-4970 1073-449X |
| DOI: | 10.1164/rccm.200306-779oc |
| Popis: | Information concerning the impact of environmental factors on cystic fibrosis (CF) is limited. We conducted a cohort study to assess the impact of air pollutants in CF. The study included patients over the age of 6 years enrolled in the Cystic Fibrosis Foundation National Patient Registry in 1999 and 2000. Exposure was assessed by linking air pollution values from the Aerometric Information Retrieval System with the patients' home zip code. After adjusting for confounders, a 10 microg/m(3) rise in particulate matter (both with a median aerodynamic diameter of 10 microm (PM(10)) or less and with an aerodynamic diameter of 2.5 microm or less (PM(2.5)) was associated with an 8% (95% confidence interval [CI], 2-15%) and 21% (95% CI, 7-33%) increase in the odds of two or more exacerbations, respectively; a 10-ppb rise in ozone was associated with a 10% (95% CI, 3-17%) increase in odds of two or more exacerbations. For every increase in PM(2.5) of 10 microg/m(3), there was an associated fall in FEV(1) of 24 ml (7-40) (95% CI) after adjusting for confounders. PM(2.5)'s association with mortality did not achieve statistical significance (adjusted RR = 1.32 per 10 microg/m(3) 0.91-1.93; 95% CI). Annual average exposures to particulate air pollution was associated with an increased risk of pulmonary exacerbations and a decline in lung function, suggesting a role of environmental exposures on prognosis in CF. |
| Databáze: | OpenAIRE |
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