Plant Mitochondrial Carriers: Molecular Gatekeepers That Help to Regulate Plant Central Carbon Metabolism
| Autor: | Joshua L. Heazlewood, M Rey Toleco, Thomas Naake, Youjun Zhang, Alisdair R. Fernie |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
0106 biological sciences
0301 basic medicine mcf oxidative phosphorylation Review Plant Science Oxidative phosphorylation transporters Mitochondrion 01 natural sciences 03 medical and health sciences Inner mitochondrial membrane Ecology Evolution Behavior and Systematics tca cycle Ecology Chemistry Botany Mitochondrial carrier Cell biology Citric acid cycle Cytosol 030104 developmental biology MCF TCA cycle mitochondrial carriers QK1-989 Flux (metabolism) Function (biology) 010606 plant biology & botany |
| Zdroj: | Plants, Vol 9, Iss 1, p 117 (2020) Plants |
| ISSN: | 2223-7747 |
| DOI: | 10.3390/plants9010117 |
| Popis: | The evolution of membrane-bound organelles among eukaryotes led to a highly compartmentalized metabolism. As a compartment of the central carbon metabolism, mitochondria must be connected to the cytosol by molecular gates that facilitate a myriad of cellular processes. Members of the mitochondrial carrier family function to mediate the transport of metabolites across the impermeable inner mitochondrial membrane and, thus, are potentially crucial for metabolic control and regulation. Here, we focus on members of this family that might impact intracellular central plant carbon metabolism. We summarize and review what is currently known about these transporters from in vitro transport assays and in planta physiological functions, whenever available. From the biochemical and molecular data, we hypothesize how these relevant transporters might play a role in the shuttling of organic acids in the various flux modes of the TCA cycle. Furthermore, we also review relevant mitochondrial carriers that may be vital in mitochondrial oxidative phosphorylation. Lastly, we survey novel experimental approaches that could possibly extend and/or complement the widely accepted proteoliposome reconstitution approach. |
| Databáze: | OpenAIRE |
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