Patients with activated B-cell like diffuse large B-cell lymphoma in high and low infectious disease areas have different inflammatory gene signatures
| Autor: | Abdel-Rahman N. Zekri, Therese Högfeldt, Joachim Lundahl, Katja Pokrovskaja Tamm, Abeer A. Bahnassy, Ali Moshfegh, Håkan Mellstedt, Anders Österborg, Hussein M. Khaled, Anna Porwit, Anna Kwiecinska |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Cancer Research Environment Biology Lymphocyte Activation Receptor Tyrosine Kinase-like Orphan Receptors immune system diseases hemic and lymphatic diseases Gene expression medicine Humans B cell Aged Aged 80 and over Inflammation Sweden Regulation of gene expression B-Lymphocytes Gene Expression Profiling Hematology Middle Aged medicine.disease Lymphoma Gene Expression Regulation Neoplastic Gene expression profiling STAT Transcription Factors medicine.anatomical_structure Real-time polymerase chain reaction Oncology Virus Diseases ROR1 Immunology Cancer research Egypt Female Gene-Environment Interaction Lymphoma Large B-Cell Diffuse Diffuse large B-cell lymphoma Signal Transduction |
| Zdroj: | Leukemia & Lymphoma. 54:996-1003 |
| ISSN: | 1029-2403 1042-8194 |
| DOI: | 10.3109/10428194.2012.738365 |
| Popis: | Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease with an association with inflammation and viral infections. We hypothesize that environmental factors may be involved in the pathogenesis of DLBCL. In this study, we compared gene expression profiles of lymph node tissues from patients with DLBCL from two different geographical areas with diverse environmental exposures. Specimens from Egyptian and Swedish patients with DLBCL as well as controls were studied. Gene expression analysis using microarray and quantitative polymerase chain reaction demonstrated significantly higher expression of signal transducer and activator of transcription 3 (STAT3) in Swedish as compared to Egyptian patients and control materials from both countries. This was confirmed at protein level using confocal microscopy. The receptor tyrosine kinase ROR1, a "survival factor" for malignant cells, was overexpressed and significantly related to the STAT3 expression pattern. The difference in the expression of genes involved in inflammatory responses and in the tumorigenic process of DLBCL might relate to infectious agents and/or other environmental exposures. |
| Databáze: | OpenAIRE |
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