Neuroticism, Smoking, and the Risk of Parkinson’s Disease
| Autor: | Karin Wirdefeldt, Yiqiang Zhan, Nancy L. Pedersen, Johanna Sieurin |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Research Report
0301 basic medicine Genome-wide association study Disease smoking Cohort Studies 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Meta-Analysis as Topic genetics [Parkinson Disease] Risk Factors epidemiology [Smoking] mental disorders Mendelian randomization Humans SNP Medicine ddc:610 Genetic association Neuroticism business.industry Smoking Parkinson Disease genetics [Smoking] Odds ratio Mendelian Randomization Analysis mendelian randomization 030104 developmental biology Parkinson’s disease epidemiology [Parkinson Disease] Neurology (clinical) business 030217 neurology & neurosurgery Genome-Wide Association Study Clinical psychology Cohort study |
| Zdroj: | Journal of Parkinson's Disease 11(3), 1325-1334 (2021). doi:10.3233/JPD-202522 Journal of Parkinson's Disease |
| ISSN: | 1877-718X 1877-7171 |
| DOI: | 10.3233/jpd-202522 |
| Popis: | Background: The relationship among neuroticism, smoking, and Parkinson’s disease (PD) is less examined. Objective: To examine the causal associations between neuroticism, smoking initiation, and the risk of PD. Methods: We performed a two-sample Mendelian randomization (MR) design in a network framework. Summary statistics from meta-analyses of genome-wide association studies (GWAS) were based on large cohorts of European ancestry. Study participants were from various cohort studies for neuroticism and smoking initiation, and case-control studies or cohort studies of PD from previously published GWAS meta-analyses. Patients with PD were ascertained from either clinical visit or self-reported. Results: The two-sample MR analysis showed no evidence for a causal association between neuroticism and PD risk (odds ratio [OR] 0.86, 95%confidence intervals [CIs] 0.67 to 1.12). While we did not find a significant association between neuroticism and PD, one SNP, rs58879558 (located in MAPT region), was associated with both neuroticism and PD. We found a significant association of neuroticism on smoking initiation (OR: 1.10, 95%CI: 1.05 to 1.14). Further, our results provided evidence for a protective effect of smoking initiation on the risk of PD (OR: 0.75, 95%CI: 0.62 to 0.91). Conclusion: These findings do not support a causal association of neuroticism on PD risk. However, they provide evidence for a causal relationship between neuroticism and smoking initiation and a strong causal effect of smoking initiation on a reduced risk of PD. |
| Databáze: | OpenAIRE |
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