Supraclavicular Brown Adipose Tissue 18F-FDG Uptake and Cardiovascular Disease

Autor: Meghan H. MacNabb, Marielle Scherrer-Crosbie, Richard A.P. Takx, Amorina Ishai, Ahmed Tawakol, Quynh A. Truong
Rok vydání: 2016
Předmět:
Adult
0301 basic medicine
medicine.medical_specialty
Adipose tissue
Coronary Artery Disease
Disease
030204 cardiovascular system & hematology
Risk Assessment
Sensitivity and Specificity
Disease-Free Survival
03 medical and health sciences
0302 clinical medicine
Adipose Tissue
Brown
Fluorodeoxyglucose F18
Risk Factors
Positron Emission Tomography Computed Tomography
Internal medicine
Hounsfield scale
Brown adipose tissue
Prevalence
medicine
Humans
Tissue Distribution
Radiology
Nuclear Medicine and imaging
Coronary atherosclerosis
Aged
medicine.diagnostic_test
business.industry
Reproducibility of Results
Cancer
Middle Aged
medicine.disease
Clavicle
030104 developmental biology
medicine.anatomical_structure
Positron emission tomography
Cardiology
Radiopharmaceuticals
business
Body mass index
Boston
Zdroj: Journal of Nuclear Medicine. 57:1221-1225
ISSN: 2159-662X
0161-5505
Popis: Preclinical data suggest a negative correlation between brown adipose tissue (BAT) and the degree of coronary atherosclerosis. We sought to evaluate the relationship between (18)F-FDG uptake in supraclavicular BAT in relation to arterial inflammation and subsequent cardiovascular disease (CVD) events in humans.Individuals who underwent (18)F-FDG PET/CT for clinical indications but who did not have either cancer or known atherosclerotic disease at the time of imaging were included. A radiologist masked to clinical data measured (18)F-FDG uptake within BAT (in the supraclavicular region) as well as in subcutaneous adipose tissues. Tissue density was evaluated using CT (Hounsfield units). Arterial inflammation was assessed by measuring arterial (18)F-FDG uptake and calculating target-to-background ratio. CVD events were independently adjudicated by masked cardiologists. Thereafter, the relationship between BAT activity and CVD events was evaluated.A total of 443 patients (age, 55 y [44-66 y]; 44% men; body mass index [BMI], 26 [range, 23-31]) were included, and 30 patients experienced a cardiovascular event during a median follow-up of 4 y. BAT activity negatively correlated with arterial inflammation (r = -0.178, P0.01), a relationship that persisted after correcting for age and BMI (r = -0.147, P0.01). When either high sensitivity or high accuracy thresholds (from receiver-operating curve analyses) were used to define elevated BAT, high BAT was associated with a reduced risk of CVD events (P = 0.048), even after correcting for age (P = 0.037).Our results suggest that increased supraclavicular BAT activity is inversely associated with arterial inflammation, independently of age and BMI. Additionally, increased BAT may be associated with fewer cardiovascular events.
Databáze: OpenAIRE
Externí odkaz: