Synthesis and biological activities of 3-aminomethyl-1,2-dihydronaphthalene derivatives
| Autor: | Akio Miyake, Katsumi Itoh, Minoru Hirata, Yoshikazu Oka, Masao Tanabe |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Bicyclic molecule
Vasodilator Agents Ether Biological activity General Chemistry General Medicine Naphthalenes medicine.disease chemistry.chemical_compound Sodium borohydride Piperazine Dogs chemistry Drug Discovery medicine Animals Organic chemistry Dehydration Hydrogen chloride Mannich reaction Antihypertensive Agents |
| Zdroj: | Chemical and Pharmaceutical Bulletin. 31:2006-2015 |
| ISSN: | 1347-5223 0009-2363 |
| DOI: | 10.1248/cpb.31.2006 |
| Popis: | A series of 3-aminomethyl-1, 2-dihydronaphthalene derivatives (6-22) was prepared from the corresponding 3, 4-dihydro-1 (2H)-naphthalenone derivatives (24a-q) in three steps, namely the Mannich reaction, reduction of the carbonyl group with sodium borohydride, and dehydration with ethanolic hydrogen chloride. Compounds 6-22 and several related analogs (23, 27-30) were tested for vasodilating and antihypertensive activities. Potent cerebral vasodilating and antihypertensive activities were exhibited by 1-benzhydryl-4-(7-disubstituted amino-1, 2-dihydro-3-naphthyl) methylpiperazines (16, 18 and 19). |
| Databáze: | OpenAIRE |
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