Lifetime cumulative exposure to rubber dust, fumes and N-nitrosamines and non-cancer mortality: a 49-year follow-up of UK rubber factory workers

Autor: Damien McElvenny, John W. Cherrie, Peter Ritchie, Raymond M Agius, Mira Hidajat, Frank de Vocht, William Mueller, Andrew Darnton
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Adult
Male
longitudinal studies mortality studies rubber
medicine.medical_specialty
Nitrosamines
Respiratory Tract Diseases
Cumulative Exposure
Disease
complex mixtures
03 medical and health sciences
Liver disease
0302 clinical medicine
rubber manufacturing industry
Risk Factors
Neoplasms
Occupational Exposure
Environmental health
Epidemiology
medicine
Humans
COHORT
030212 general & internal medicine
Asthma
business.industry
MORTALITY
Respiratory disease
Public Health
Environmental and Occupational Health
technology
industry
and agriculture
RUBBER
Dust
Middle Aged
medicine.disease
Survival Analysis
030210 environmental & occupational health
United Kingdom
Occupational Diseases
Cardiovascular Diseases
Chronic Disease
occupational health
Cohort
Bronchitis
epidemiology
Rubber
business
Environmental Monitoring
Follow-Up Studies
Zdroj: Hidajat, M, McElvenny, D M, Ritchie, P, Darnton, A, Mueller, W, Agius, R M, Cherrie, J W & de Vocht, F 2020, ' Lifetime cumulative exposure to rubber dust, fumes and N-nitrosamines and non-cancer mortality: a 49-year follow-up of UK rubber factory workers ', Occup Environ Med . https://doi.org/10.1136/oemed-2019-106269, https://doi.org/https://research-information.bris.ac.uk/files/219418363/Hidajat_et_al._OEM_author_accepted_version.pdf
Hidajat, M, McElvenny, D M, Ritchie, P, Darnton, A, Mueller, W, Agius, R M, Cherrie, J W & de Vocht, F 2020, ' Lifetime cumulative exposure to rubber dust, fumes and N-nitrosamines and non-cancer mortality : a 49-year follow-up of UK rubber factory workers ', Occupational and Environmental Medicine . https://doi.org/10.1136/oemed-2019-106269
DOI: 10.1136/oemed-2019-106269
Popis: ObjectivesTo examine associations between occupational exposures to rubber dust, rubber fumes and N-nitrosamines and non-cancer mortality.MethodsA cohort of 36 441 males aged 35+ years employed in British rubber factories was followed-up to 2015 (94% deceased). Competing risk survival analysis was used to assess risks of dying from non-cancer diseases (respiratory, urinary, cerebrovascular, circulatory and digestive diseases). Occupational exposures to rubber dust, rubber fumes, N-nitrosamines were derived based on a population-specific quantitative job-exposure matrix which in-turn was based on measurements in the EU-EXASRUB database.ResultsExposure–response associations of increased risk with increasing exposure were found for N-nitrosomorpholine with mortality from circulatory diseases (subdistribution hazard ratio (SHR) 1.17; 95% CI 1.12 to 1.23), ischaemic heart disease (IHD) (SHR 1.19; 95% CI 1.13 to 1.26), cerebrovascular disease (SHR 1.19; 95% CI 1.07 to 1.32) and exposures to N-nitrosodimethylamine with respiratory disease mortality (SHR 1.41; 95% CI 1.30 to 1.53). Increased risks for mortality from circulatory disease, IHD and digestive diseases were found with higher levels of exposures to rubber dust, rubber fumes and N-nitrosamines sum, without an exposure-dependent manner. No associations were observed between rubber dust, rubber fumes and N-nitrosamines exposures with mortality from asthma, urinary disease, bronchitis, emphysema, liver disease and some digestive diseases.ConclusionsIn a cohort of rubber factory workers with 49 years of follow-up, increased risk for mortality from circulatory, cerebrovascular, respiratory and digestive diseases were found to be associated with cumulative occupational exposures to specific agents.
Databáze: OpenAIRE
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