Removing Control of Cyclodextrin-Drug Complexes Using High Affinity Molecule

Autor: Dong-Jin Jang, Dongjin Kang, Kyeongsoon Kim, Taeyong Sim, Dae-Young Kim, Sang Yeob Park, Jun-Pil Jee, Kwan Hyung Cho, Sung Tae Kim, Y. N. Kim
Rok vydání: 2018
Předmět:
Drug
Materials science
media_common.quotation_subject
Biomedical Engineering
Supramolecular chemistry
Infrared spectroscopy
Bioengineering
macromolecular substances
02 engineering and technology
030226 pharmacology & pharmacy
03 medical and health sciences
0302 clinical medicine
Drug Delivery Systems
Spectroscopy
Fourier Transform Infrared
Molecule
Nanotechnology
General Materials Science
Dissolution testing
Solubility
media_common
chemistry.chemical_classification
Cyclodextrins
Cyclodextrin
Calorimetry
Differential Scanning
Cyclooxygenase 2 Inhibitors
beta-Cyclodextrins
General Chemistry
021001 nanoscience & nanotechnology
Condensed Matter Physics
Combinatorial chemistry
Bioavailability
2-Hydroxypropyl-beta-cyclodextrin
chemistry
Celecoxib
0210 nano-technology
Hydrophobic and Hydrophilic Interactions
Zdroj: Journal of nanoscience and nanotechnology. 18(2)
ISSN: 1533-4880
Popis: Nanostructured supramolecular assemblies with hydrophobic cavities are used for improving the solubility, bioavailability, and stability of poorly water soluble drugs. In particular, host-guest inclusion using 2-hydroxypropyl-beta-cyclodextrin (HP-β-CD) is a typical approach in the pharmaceutical field. In this study, celecoxib (CXB), a cyclooxygenase-2 selective nonsteroidal anti-inflammatory drug (NSAID), was used as the model drug (guest material) and effectively incorporated into HP-β-CD (host material). After forming a complete complex of HP-β-CD and CXB, 1-adamantylamine (ADA) was used to allow CXB to be released from the HP-β-CD in a concentration-dependent manner. This was revealed from Fourier-transform infrared spectroscopy and drug dissolution studies. Notably, the use of ADA, which is a high-affinity guest molecule, with cyclodextrin accelerated the removal of CXB from the host material through the exchange of guest molecules. Taken together, the host-guest based approach using a second guest molecule is useful for regulating on-demand drug release and could therefore be a potential tool for biomedical applications.
Databáze: OpenAIRE
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