Pharmacological-assisted Psychotherapy for Post Traumatic Stress Disorder: a systematic review and meta-analysis

Autor:	Matthew R. D. Lee, Neil P. Roberts, Jonathan Ian Bisson, Jack F. G. Underwood, R. Sinnerton, Alan Slater, Mathew Hoskins, Anna Nakamura, Catrin Lewis, Liam Clarke
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	ISRS 050103 clinical psychology medicine.medical_specialty drug-assisted therapy d-cycloserine Psychological intervention RC435-571 Placebo Mean difference 03 medical and health sciences 0302 clinical medicine 药物治疗 Intervention (counseling) Medicine ptsd 0501 psychology and cognitive sciences Stage (cooking) ISRN snri Psychiatry Clinical Research Article business.industry 05 social sciences Traumatic stress D-cicloserina ssri Experimental research terapia asistida por fármacos 030227 psychiatry mdma D-环丝氨酸 Meta-analysis Terapia farmacológica Physical therapy 药物辅助治疗 business pharmacological therapy Research Article
Zdroj:	European Journal of Psychotraumatology, Vol 12, Iss 1 (2021) European Journal of Psychotraumatology article-version (VoR) Version of Record
ISSN:	2000-8066 2000-8198
Popis:	Background: Pharmacological-assisted psychotherapies, using conventional and novel drug agents, are increasingly being used both in clinical and experimental research settings, respectively. Objective: To determine the efficacy of conventional and novel pharmacological-assisted psychotherapies in reducing PTSD symptom severity. Method: A systematic review and meta-analysis of randomised-controlled trials were undertaken; 21 studies were included. Results: MDMA-assisted therapy was found to statistically superior to active and inactive placebo-assisted therapy in reduction of PTSD symptoms (standardised mean difference −1.09, 95% CI −1.60 to −0.58). There was no evidence of superiority over placebo for any other intervention. Conclusions: MDMA-assisted therapy demonstrated an impressive effect size; however, it is difficult to have confidence at this stage in this intervention due to the small numbers of participants included, and more research in this area is needed. There was no evidence to support the efficacy of any other drug-assisted interventions. Summary HIGHLIGHTS • We found that MDMA-assisted therapy is a novel and promising new treatment for severe PTSD. • Despite demonstrating an impressive effect size, more research is needed due to the small numbers of participants included. • We did not find evidence to recommend any other drug-assisted psychological intervention.
Databáze:	OpenAIRE
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