Nucleic acid structure and expression of the human AIDS/lymphadenopathy retrovirus
| Autor: | Daniel J. Capon, Mark A. Muesing, Charles V. Benton, Laurence A. Lasky, C. D. Cabradilla, Douglas H. Smith |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Genes
Viral Transcription Genetic viruses DNA Recombinant Deltaretrovirus Virus Viral Proteins Retrovirus Viral Envelope Proteins Complementary DNA Humans Nucleic acid structure Gene Subgenomic mRNA Genetics Acquired Immunodeficiency Syndrome Multidisciplinary Base Sequence biology Nucleic Acid Hybridization RNA DNA Provirus biology.organism_classification Virology Protein Biosynthesis RNA Viral |
| Zdroj: | Nature. 313:450-458 |
| ISSN: | 1476-4687 0028-0836 |
| DOI: | 10.1038/313450a0 |
| Popis: | The 9,213-nucleotide structure of the AIDS/lymphadenopathy virus has been determined from molecular clones representing the integrated provirus and viral RNA. The sequence reveals that the virus is highly polymorphic and lacks significant nucleotide homology with type C retroviruses characterized previously. Together with an analysis of the two major viral subgenomic RNAs, these studies establish the coding frames for the gag, pol and env genes and predict the expression of a novel gene at the 3' end of the genome unrelated to the X genes of HTLV-1 and -II. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|