1,25-dihydroxyvitamin D3 and development of tuberculosis in cattle
| Autor: | Jayne Hope, L.A. Terry, Shelley G. Rhodes, R. G. Hewinson, H. M. Vordermeier |
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| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
Microbiology (medical)
Calcitriol/analysis T-Lymphocytes Clinical Biochemistry Immunology Tuberculosis Bovine/metabolism Antigens CD80/analysis Leukocytes Mononuclear/chemistry Lymphocyte Activation/immunology Lymphocyte Activation Calcitriol receptor Peripheral blood mononuclear cell Veterinary Immunology Calcitriol medicine Immunology and Allergy Animals Granuloma/etiology Antigen-presenting cell Mycobacterium bovis Granuloma biology T-Lymphocytes/immunology medicine.disease biology.organism_classification biology.protein B7-1 Antigen Leukocytes Mononuclear Lymph Nodes/pathology Immunohistochemistry Cattle Lymph Nodes Antibody Tuberculosis Bovine CD80 Calcitriol/physiology |
| Zdroj: | Rhodes, S G, Terry, L A, Hope, J, Hewinson, R G & Vordermeier, H M 2003, ' 1,25-dihydroxyvitamin D3 and development of tuberculosis in cattle ', Clinical and Diagnostic Laboratory Immunology, vol. 10, no. 6, pp. 1129-35 . |
| Popis: | This report describes the presence and activity of 1,25-dihydroxyvitamin D 3 (1,25-D 3 ) in experimental bovine tuberculosis. Animals that went on to develop tuberculous lesions exhibited a rapid transient increase in serum 1,25-D 3 within the first 2 weeks following infection with Mycobacterium bovis . 1,25-D 3 -positive mononuclear cells were later identified in all tuberculous granulomas by immunohistochemical staining of postmortem lymph node tissue. These results suggest a role for 1,25-D 3 both at the onset of infection and in the development of the granuloma in these infected animals. Using a monoclonal antibody to the vitamin D receptor (VDR) as a VDR agonist, we confirmed that activation of the vitamin D pathway profoundly depresses antigen-specific, but not mitogenic, bovine peripheral blood T-cell responses (proliferation and gamma interferon production). Investigation of the mechanism of this suppression showed that the VDR antibody modified the expression of CD80 by accessory cells, such that a significant positive correlation between T-cell proliferation and accessory cell CD80 emerged. |
| Databáze: | OpenAIRE |
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