RNA modifications in cardiovascular diseases, the potential therapeutic targets
| Autor: | Yizhou Xu, Siyao Zhan, Xiangwei Gao, Yirong Wu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Adenosine RNA Untranslated RNA methylation Hypertension Pulmonary Coronary Disease Computational biology Biology Methylation 030226 pharmacology & pharmacy General Biochemistry Genetics and Molecular Biology Pseudouridine Epigenesis Genetic Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Animals Humans Regeneration Epigenetics RNA Processing Post-Transcriptional General Pharmacology Toxicology and Pharmaceutics Heart Failure Metabolic Syndrome Messenger RNA Gene Expression Profiling Microcirculation Myocardium RNA Hypertrophy General Medicine Ribosomal RNA Atherosclerosis Non-coding RNA Fibrosis 030104 developmental biology Gene Expression Regulation chemistry Cardiovascular Diseases Reperfusion Injury Transfer RNA Transcriptome |
| Zdroj: | Life Sciences. 278:119565 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/j.lfs.2021.119565 |
| Popis: | More than one hundred RNA modifications decorate the chemical and topological properties of these ribose nucleotides, thereby executing their biological functions through post-transcriptional regulation. In cardiovascular diseases, a wide range of RNA modifications including m6A (N6-adenosine methylation), m5C (5-methylcytidin), Nm (2'-O-ribose-methylation), Ψ (pseudouridine), m7G (N7-methylguanosine), and m1A (N1-adenosine methylation) have been found in tRNA, rRNA, mRNA and other noncoding RNA, which can function as a novel mechanism in metabolic syndrome, heart failure, coronary heart disease, and hypertension. In this review, we will summarize the current understanding of the regulatory roles and significance of several types of RNA modifications in CVDs (cardiovascular diseases) and the interplay between RNA modifications and noncoding RNA, epigenetics. Finally, we will focus on the potential therapeutic strategies by using RNA modifications. |
| Databáze: | OpenAIRE |
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