Hepatitis B, C and Delta virus infections in Albanian patients with chronic liver disease: evaluation of possible changes during the last 10 years
| Autor: | Gloria Taliani, Liri Çuko, Bashkim Resuli, Maurizia Rossana Brunetto, Paola Chionne, Loreta A. Kondili, Elisabetta Madonna, Maria Rapicetta, Pietro Dentico, Angela Candido |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Hepatitis B virus Alcoholic liver disease medicine.medical_specialty HBsAg Time Factors Adolescent Alcohol Drinking Hepatitis D Chronic Hepacivirus medicine.disease_cause Chronic liver disease Gastroenterology Young Adult Hepatitis B Chronic hepatitis delta virus alcohol chronic liver disease albania hepatitis b virus hepatitis c virus Internal medicine Prevalence medicine Humans Hepatitis B e Antigens Liver Diseases Alcoholic Aged Aged 80 and over Hepatitis B Surface Antigens Hepatology business.industry virus diseases Hepatitis C Hepatitis C Antibodies Middle Aged Hepatitis B medicine.disease Hepatitis D digestive system diseases Albania DNA Viral Immunology RNA Viral Female Hepatitis Delta Virus Viral hepatitis business |
| Zdroj: | European Journal of Gastroenterology & Hepatology. 22:167-171 |
| ISSN: | 0954-691X |
| Popis: | Objective and methods The prevalence of viral hepatitis markers and of alcohol intake was evaluated in 106 and 99 Albanian patients with the diagnosis of viral and/or alcoholic chronic liver disease who were consecutively admitted to the University Hospital Center of Tirana, during 1995 and 2005, respectively. Results A slight decrease in HBsAg (78 vs. 70%) and HBeAg (18 vs. 12%) prevalences were observed in patients admitted to the hospital during 2005 compared with those admitted during 1995, respectively. In both periods of time, hepatitis B virus (HBV) DNA (genotype D) tested positive in all HBsAg-positive patients and in 36% of HBsAg-negative patients. Anti-hepatitis C virus (HCV) prevalence (mainly observed after 30 years of age) was 14 versus 11%; anti-hepatitis Delta virus (HDV) prevalence (more frequently present in young age group patients) was 9 versus 7% during 1995 and 2005, respectively. Among patients who reported alcohol intake, alcoholic liver disease (HBsAg and anti-HCV negative) was diagnosed in 35 and in 57% of patients admitted during 1995 and 2005, respectively (P = 0.05). Conclusion In Albanian patients with chronic liver disease, we have found that: (i) HBV remained the most important aetiologic factor of chronic liver disease; HDV and HCV prevalences were still low, (ii) in HBsAg-positive patients, HBeAg-negative chronic hepatitis prevailed, (iii) in HBsAg-negative patients, HBV DNA prevalence was high, (iv) during the last decade, an increased prevalence of alcohol intake in the aetiology of chronic liver disease was observed. |
| Databáze: | OpenAIRE |
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