Perioperative subconjunctival triamcinolone acetonide injection for prevention of inflammation and macular oedema after cataract surgery
| Autor: | Juha-Matti Lindholm, Claudia Taipale, Petteri Ylinen, Raimo Tuuminen |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Intraocular pressure Triamcinolone acetonide genetic structures medicine.medical_treatment Visual Acuity Triamcinolone Acetonide Macular Edema Injections 03 medical and health sciences 0302 clinical medicine Endophthalmitis medicine Humans Prospective Studies Glucocorticoids Dexamethasone Aged Postoperative Care Phacoemulsification Dose-Response Relationship Drug business.industry General Medicine Perioperative Cataract surgery medicine.disease eye diseases 3. Good health Surgery Ophthalmology Treatment Outcome Tolerability 030221 ophthalmology & optometry Female sense organs business Conjunctiva 030217 neurology & neurosurgery Follow-Up Studies medicine.drug |
| Zdroj: | Acta Ophthalmologica. 98:36-42 |
| ISSN: | 1755-3768 1755-375X |
| Popis: | Purpose To compare the efficacy, safety and tolerability of a single perioperative subconjunctival injection of triamcinolone acetonide (TA) with steroid drops for the prevention of macular oedema and ocular inflammation after cataract surgery. Methods This prospective non-randomized controlled clinical trial analysed 101 eyes of 101 patients having an elective cataract surgery at Kymenlaakso Central Hospital, Kotka, Finland. Fifty eyes received conventional postoperative care with dexamethasone 1 mg/ml eye drops (DEX), and 51 eyes received a perioperative 20 mg subconjunctival injection of TA. None of the eyes received postoperative topical antibiotic prophylaxis. The main outcome measures were aqueous flare, central retinal thickness (CRT), corrected distance visual acuity (CDVA) and intraocular pressure (IOP) measured at 7, 28 and 90 days after surgery. Results Central retinal thickness (CRT) increased in DEX but not in TA-treated eyes at 7 days (+1.2 ± 20.1 μm and -9.2 ± 24.8 μm, p = 0.031), at 28 days (+23.8 ± 62.6 μm and -3.3 ± 27.7 μm, p = 0.008) and at 90 days (+8.5 ± 24.4 μm and -5.5 ± 33.4 μm, p = 0.026). Aqueous flare increased from baseline in both groups but remained higher in DEX eyes at 90 days (+3.3 ± 9.9 photons/ms and -0.2 ± 6.6 photons/ms, p = 0.021). Corrected distance visual acuity (CDVA) and IOP changes were similar, and ocular tolerance was good in both groups. No serious adverse events were observed. Conclusions Perioperative subconjunctival TA was effective in preventing ocular inflammation and macular oedema after cataract surgery. Subconjunctival TA combined with intracameral cefuroxime provides a noteworthy option for dropless postoperative care in modern cataract surgery. |
| Databáze: | OpenAIRE |
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