Navigation rules for vessels and neurons: cooperative signaling between VEGF and neural guidance cues
| Autor: | Sophie Chauvet, Katja Burk, Fanny Mann |
|---|---|
| Přispěvatelé: | Institut de Biologie du Développement de Marseille (IBDM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2013 |
| Předmět: |
Vascular Endothelial Growth Factor A
MESH: Signal Transduction MESH: Axons MESH: Lymphatic Vessels Angiogenesis MESH: Receptors Eph Family VEGF receptors Cellular differentiation MESH: Neurons Receptors Cell Surface MESH: Semaphorins Semaphorins [SDV.BC]Life Sciences [q-bio]/Cellular Biology Biology 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Animals Humans MESH: Animals Neuropilins Growth cone Molecular Biology Neural cell Lymphatic Vessels Receptors Eph Family MESH: Receptors Cell Surface 030304 developmental biology Neurons Pharmacology 0303 health sciences MESH: Humans MESH: Vascular Endothelial Growth Factor Receptor-2 MESH: Vascular Endothelial Growth Factor A MESH: Blood Vessels Cell Biology Anatomy Vascular Endothelial Growth Factor Receptor-2 Axons Lymphatic system biology.protein Blood Vessels Molecular Medicine Axon guidance MESH: Neuropilins Signal transduction Neuroscience 030217 neurology & neurosurgery Signal Transduction |
| Zdroj: | Cellular and Molecular Life Sciences Cellular and Molecular Life Sciences, 2013, 70 (10), pp.1685-703. ⟨10.1007/s00018-013-1278-4⟩ Cellular and Molecular Life Sciences, Springer Verlag, 2013, 70 (10), pp.1685-703. ⟨10.1007/s00018-013-1278-4⟩ |
| ISSN: | 1420-9071 1420-682X |
| DOI: | 10.1007/s00018-013-1278-4 |
| Popis: | International audience; Many organs, such as lungs, nerves, blood and lymphatic vessels, consist of complex networks that carry flows of information, gases, and nutrients within the body. The morphogenetic patterning that generates these organs involves the coordinated action of developmental signaling cues that guide migration of specialized cells. Precision guidance of endothelial tip cells by vascular endothelial growth factors (VEGFs) is well established, and several families of neural guidance molecules have been identified to exert guidance function in both the nervous and the vascular systems. This review discusses recent advances in VEGF research, focusing on the emerging role of neural guidance molecules as key regulators of VEGF function during vascular development and on the novel role of VEGFs in neural cell migration and nerve wiring. |
| Databáze: | OpenAIRE |
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