Grand mal convulsion and plasma concentrations after intravascular injection of ropivacaine for axillary brachial plexus blockade
| Autor: | Matthias Hübler, Rainer J. Litz, M. Müller, D. M. Albrecht |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
business.industry Ropivacaine Nerve Block Venous blood Amides Blockade Anesthesiology and Pain Medicine Pharmacokinetics Anesthesia Injections Intravenous Toxicity Convulsion Humans Medicine Brachial Plexus Epilepsy Tonic-Clonic Anesthetics Local medicine.symptom Complication business Brachial plexus Aged medicine.drug |
| Zdroj: | British Journal of Anaesthesia. 87:784-787 |
| ISSN: | 0007-0912 |
| Popis: | We report a patient to whom ropivacaine 1.1 mg kg(-1) was administered for brachial plexus blockade and who developed grand mal convulsions because of inadvertent i.v. injection. No symptoms of cardiovascular toxicity occurred. Venous blood samples were taken 15, 45, 75 and 155 min after the injection. The measured total plasma concentrations of ropivacaine were 3.3, 1.6, 1.2 and 1.0 mg litre(-1) respectively. Initial plasma concentration after the end of the injection period was estimated at 5.75 mg litre(-1) using a two-compartment pharmacokinetic model. |
| Databáze: | OpenAIRE |
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