Relationship between Changes in Plasma Leptin Concentrations and Plasminogen Activator Inhibitor-1 in Obese Prepubertal Children after Nine Months of Treatment
| Autor: | Rosario Valle, Miguel Valle Jiménez, Francisco Bermudo, Ramón Cañete, M. Mar Urbano, María Dolores Cañete, Rosario M. Morales, Rosario Martos |
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| Rok vydání: | 2013 |
| Předmět: |
Leptin
Male medicine.medical_specialty medicine.medical_treatment Medicine (miscellaneous) Body Mass Index chemistry.chemical_compound Insulin resistance Internal medicine Plasminogen Activator Inhibitor 1 Blood plasma Fibrinolysis medicine Humans Insulin Longitudinal Studies Obesity Child Triglycerides Metabolic Syndrome Nutrition and Dietetics Apolipoprotein A-I business.industry Cholesterol HDL medicine.disease Cross-Sectional Studies Endocrinology chemistry Plasminogen activator inhibitor-1 Female Insulin Resistance Metabolic syndrome business Plasminogen activator |
| Zdroj: | Annals of Nutrition and Metabolism. 63:216-222 |
| ISSN: | 1421-9697 0250-6807 |
| Popis: | Background/Aims: The metabolic syndrome (MS) is associated with insulin resistance (IR), inappropriate fibrinolysis and high plasma leptin concentrations. The aim of this study was to quantify fibrinolysis and MS-related variables in obese prepubertal children and to evaluate changes in these variables as a result of improved body mass index (BMI), IR and leptin levels following 9 months of treatment. Methods: The homeostasis model assessment for insulin resistance (HOMA-IR), leptin, plasminogen activator inhibitor-1 (PAI-1) and lipid profile were studied at baseline in obese (n = 50) and nonobese children (n = 50), and after 9 months of treatment in obese children. Results: In the cross-sectional study the mean values for insulin, HOMA-IR, triglycerides, leptin and PAI-1 were significantly higher in obese children than in controls. High-density lipoprotein cholesterol (HDLc) and apolipoprotein A-1 were significantly lower. In the longitudinal study, after 9 months, children with lowered BMI standard deviation score displayed a significant decrease in insulin, HOMA-IR, PAI-1, leptin and triglyceride levels, and an increase in HDLc. Only leptin proved to be an independent predictive factor for changes in PAI-1 (p = 0.010). Conclusion: Obesity-linked disorders appear in obese children prior to puberty; these disorders can be improved by decreasing BMI. Changes in leptin levels were found to independently predict changes in PAI-1 in obese children and can help to diagnose complications associated with the obesity. |
| Databáze: | OpenAIRE |
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