Hyperbaric oxygen pretreatment according to the gas micronuclei denucleation hypothesis reduces neurologic deficit in decompression sickness in rats
| Autor: | D. Tal, Amir Abramovich, Ksenya Cohen Katsenelson, Yehuda Arieli, Moshe Feinsod, Ran Arieli |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
musculoskeletal diseases Time Factors Physiology Decompression Diving Hyperbaric oxygenation Rats Sprague-Dawley Decompression sickness Hyperbaric oxygen Evoked Potentials Somatosensory Physiology (medical) medicine Animals Oxygen toxicity Hyperbaric Oxygenation Chemistry Peroneal Nerve Decompression Sickness medicine.disease Electric Stimulation Median Nerve Rats Disease Models Animal Somatosensory evoked potential Anesthesia Micronucleus test Higher animals Gases Nervous System Diseases |
| Zdroj: | Journal of Applied Physiology. 107:558-563 |
| ISSN: | 1522-1601 8750-7587 |
| DOI: | 10.1152/japplphysiol.91557.2008 |
| Popis: | During sudden or too rapid decompression, gas is released within supersaturated tissues in the form of bubbles, the cause of decompression sickness. It is widely accepted that these bubbles originate in the tissue from preexisting gas micronuclei. Pretreatment with hyperbaric oxygen (HBO) has been hypothesized to shrink the gas micronuclei, thus reducing the number of emerging bubbles. The effectiveness of a new HBO pretreatment protocol on neurologic outcome was studied in rats. This protocol was found to carry the least danger of oxygen toxicity. Somatosensory evoked potentials (SSEPs) were chosen to serve as a measure of neurologic damage. SSEPs in rats given HBO pretreatment before a dive were compared with SSEPs from rats not given HBO pretreatment and SSEPs from non-dived rats. The incidence of abnormal SSEPs in the animals subjected to decompression without pretreatment (1,013 kPa for 32 min followed by decompression) was 78%. In the pretreatment group (HBO at 304 kPa for 20 min followed by exposure to 1,013 kPa for 33 min and decompression) this was significantly reduced to 44%. These results call for further study of the pretreatment protocol in higher animals. |
| Databáze: | OpenAIRE |
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