The efficacy of low-dose radioactive iodine without a thionamide in the treatment of thyrotoxicosis
| Autor: | Charles Bodmer, John Cameron, Ajith George, Mark Aitken |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male endocrine system diseases Adolescent Thyroid Function Tests Radiation Dosage Risk Assessment Severity of Illness Index Cohort Studies Iodine Radioisotopes Symptom relief Antithyroid Agents medicine Humans Prospective Studies Aged Probability Aged 80 and over Chi-Square Distribution business.industry Low dose Dose-Response Relationship Radiation General Medicine Middle Aged Prognosis Long-Term Care Original Papers Radiation exposure Carbimazole Thyrotoxicosis Treatment Outcome Anesthesia Female Propylthiouracil Radioactive iodine business medicine.drug |
| Zdroj: | Clinical medicine (London, England). 3(3) |
| ISSN: | 1470-2118 |
| Popis: | Between 1999 and June 2001, 55 unselected thyrotoxic patients were prescribed 200 MBq radioactive iodine (131I). None of these patients received a thionamide such as carbimazole or propylthiouracil within two weeks of treatment or subsequently. Symptom relief was achieved using beta blockers alone. Remission at one year was achieved in 84% of these patients and of these 62% were hypothyroid and taking thyroxine. Within this time, re-treatment of those who remained thyrotoxic achieved an overall success rate at one year of 95%. The outcome of 164 similar patients prescribed 250-400 MBq 131I between 1996 and 2001 gave comparable results. The failure rate after a single 200 MBq 131I dose was significantly lower than that previously published where 185 MBq 131I and thionamides had been used. Our low-dose strategy has the potential for halving the radiation exposure to the patient and the environment, when compared with the ablative strategies in common use. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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