Evaluation of Larval Therapy Compared to Antibiotic Therapy in the Treatment of Skin Wounds in Rabbits
| Autor: | Maria Carmela K.H. Duarte, Cláudia Soares Santos Lessa, Mariana dos Passos Nunes, Ana Beatriz Monteiro Fonseca, Juliana da Silva Leite, Luciano Antunes Barros, Lucas Xavier Sant’Anna, Valéria Magalhães Aguiar Coelho, Cláudio Maurício Vieira de Souza, Claudio Alessandro Massamitsu Sakamoto |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Skin wound medicine.medical_treatment Biology medicine.disease_cause Gastroenterology 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Calliphoridae Internal medicine Antibiotic therapy medicine Animals 030222 orthopedics Larva Wound Healing integumentary system General Veterinary Pseudomonas aeruginosa Bacterial Infections Necrotic tissue Anti-Bacterial Agents Infectious Diseases Amputation Insect Science Antimicrobial action Parasitology Rabbits Wound healing |
| Zdroj: | Journal of medical entomology. 58(2) |
| ISSN: | 1938-2928 |
| Popis: | Larval therapy (LT) is a therapeutic modality that uses larvae of necrophagous flies for the treatment of wounds. The use of this therapy presents several benefits, due to the action of the larvae that remove necrotic tissue selectively, exercising antimicrobial action, and promoting healing. There are situations in which LT proves to be the only or the best alternative for the patient, such as wounds infected by multidrug-resistant microorganisms or when treatment difficulties may lead to an indication for amputation. The purpose of this study was to compare the efficiency of LT, using larvae of Chrysomya megacephala, with that of antibiotic therapy in the treatment of cutaneous wounds infected with Pseudomonas aeruginosa. Twenty-four rabbits were used to perform the experiment, distributed in four groups: group 1, induced wound without bacterial infection; group 2, induced wound with bacterial infection; group 3, induced wound with bacterial infection and antibiotic therapy; group 4, induced wound with bacterial infection and LT. The macroscopic, microscopic, and statistical analyses indicated that LT was as effective as antibiotic therapy in wound healing. |
| Databáze: | OpenAIRE |
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